Bupivacaine
Conditions
Brief summary
In this study, the primary objective was to estimate the minimum effective volume of bupivacaine 0.5% resulting in successful block in 90% of patients (MEV90) for ultrasound-guided retroclavicular approach to infraclavicular brachial plexus block.
Detailed description
A biased coin up-and-down sequential design will be applied to assess the minimum effective volume in 90% of patients for the retroclavicular brachial plexus block. The first subject received 25 ml 0.5% bupivacaine . Each subsequent patient received a dose that depended on the response of the previous one. If the previous block is successful, the block will be performed either by a reduction of the volume by 2.5 ml with a probability ß = 0.11 or by a same dose of the previous one with a probability 1-ß = 0.89 in the next patient.
Interventions
The determination of MEV90 and its 95% confidence interval (CI) will be based on a biased coin up-and-down sequential design
Sponsors
Antalya Training and Research Hospital
Study design
Observational model
CASE_ONLY
Time perspective
PROSPECTIVE
Eligibility
Sex/Gender
ALL
Age
18 Years to 65 Years
Healthy volunteers
No
Inclusion criteria
* patients who received infraclavicular brachial plexus block for elective elbow, forearm, wrist, or hand surgery * American Society of Anesthesiologists class I, II or III
Exclusion criteria
* patients \<18 years old * \>65 years old * body mass index (BMI) \<20 or \>35 kg/m2 * inability to provide written informed consent * refusal of regional anesthesia * pregnancy * contraindication for regional anesthesia
Design outcomes
Primary
| Measure | Time frame | Description |
|---|---|---|
| The minimum effective volume of bupivacaine 0.5% resulting in successful block in 90% of patients (MEV90) | 30 minutes | The determination of MEV90 and its 95% confidence interval (CI) will be based on a biased coin up-and-down sequential design |
Countries
Turkey (Türkiye)
Outcome results
None listed