Healthy
Conditions
Keywords
Tool, fMRI, neuroimaging, Evolution
Brief summary
Tool use is considered to be the hallmark of complex cognitive adaptations that humans have achieved trough evolution, that provides an adaptive advantage to the human species. Even if nonhuman species do use tools too, human tool use is much more complex and sophisticated. Besides, only humans can make their tools evolve by improving them. If Man has special abilities for tool use, it has to be grounded in a specific neuroanatomical substrate. Humans and nonhumans share a similar prehension system located within the superior parietal lobe and the intraparietal sulcus. However, there is a human specificity : the surpramarginal gyrus within the left inferior parietal lobe is unique to Man, and could play a central role in tool use and tool evolution. This project aims to study the neural correlates of human tool use with functional Magnetic Resonance Imaging (fMRI), to precise the cognitive mechanisms through which humans are able to use tools. We also wish to study what are the cognitive abilities that allow us to make our tools evolve by improving them, and the neural correlates associated.
Interventions
OTHERfMRI
Imaging examination
Sponsors
Hospices Civils de Lyon
Study design
Allocation
NON_RANDOMIZED
Intervention model
SINGLE_GROUP
Primary purpose
BASIC_SCIENCE
Masking
NONE
Eligibility
Sex/Gender
ALL
Age
18 Years to 65 Years
Healthy volunteers
Yes
Inclusion criteria
* To be between the ages of 18 and 65 years old * Having given an informed consent for the study * Being right-handed * Being registered with the French Social Security System
Exclusion criteria
* No signature on the consent form, including inability to read or write French. * Neurologic or psychiatric illness, known or revealed durnig the inclusion visit * Substance intake ( taking psychoactive medications or recreational drugs) on the day of the experiment * Noise intolerance * Minor person, pregnant or breastfeeding woman * Persons under curatorship or deprived of civil rights or deprived of their freedom * Unable to fill a questionnaire (severe cognitive troubles) * Subjects must not have metallic or electronic implants in the body : pacemakers or pacemaker wires, open heart surgery, artificial heart valve, brain aneurysm surgery, middle ear implant, hearing aid, braces or extensive dental work, cataract surgery or lens implant, implanted mechanical or electrical device, or artificial limb or joint o foreign metallic objects in the body (bullets, BBs, pellets, schrapnel, or metalwork fragments) or current or past employment as machinists, welders or metal workers, tattoos near the head or neck regions, permanent makeup * Claustrophobia
Design outcomes
Primary
| Measure | Time frame | Description |
|---|---|---|
| BOLD effect | 1 hour | The measure will be the Blood Oxygenation Level Dependent measure (BOLD) as permitted with functional Magnetic Resonance Imaging. This BOLD level will be collected for every voxel in the imaged brain, and at regular time intervals (TR = 3) during the experimental session (about one hour). This is standard procedure for fMRI experiments. Functional magnetic resonance imaging measures brain activity by detecting changes associated with blood flow This technique relies on the fact that cerebral blood flow and neuronal activation are coupled. When an area of the brain is in use, blood flow to that region also increases. The primary form of fMRI uses the BOLD contrast in response to an experimental condition, allowing researchers to track changes in oxygen comsumption on the brain, and therefore brain activity. BOLD efefct is computed by assessing the different relaxation times (T1 and T2) in the brain, as T1 and T2 are different in function of regional cerebral blood flows. |
Secondary
| Measure | Time frame | Description |
|---|---|---|
| Ability to improve a tool | 20 minutes | Participants will be given metal wires and asked to build a tower as high as possible. For this, they will be able to observe the previous participant to inspire themselves. The measure collected will be the height of the tower, compared to the height of the tower of the previous participant. |
Countries
France
Outcome results
None listed