Descriptive Study of Brain Velocity in Transcranial Doppler in Newborns Over 35 Weeks of Gestational Age in the Maternity Ward

Status

Completed

Phases

Unknown

Study type

Observational

Source

ClinicalTrials.gov

Registry ID

NCT03553134

Acronym

VELOCITE

Enrollment

Registered

2018-06-12

Start date

2018-04-19

Completion date

2018-10-25

Last updated

2019-09-04

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Newborn

Brief summary

There are significant variations in blood circulation at birth with the transition from fetal to permanent circulation. These variations are particularly impacted by the closure of the arterial canal within the first 48 hours of life. Blood circulation velocity values within the cerebral arteries have been well documented in newborns and infants a few days old. However, the initial values of these velocities and their variations during the first hours of life are not well known. The objective of this study is to describe the evolution of brain circulation at birth in newborns over 35 weeks of gestational age and to investigate the effect of arterial canal closure on brain circulation.

Interventions

DIAGNOSTIC_TESTtranscranial doppler ultrasound scan

Carried out at 4 different times: at birth, 6, 24 and 48 hours of life (duration: 10 minutes)

DIAGNOSTIC_TESTultrasound scan centered on the arterial canal

Carried out at 4 different times: at birth, 6, 24 and 48 hours of life (duration: 5 minutes)

Study design

Observational model

COHORT

Time perspective

PROSPECTIVE

Eligibility

Sex/Gender

ALL

Age

No minimum to 6 Hours

Healthy volunteers

Yes

Inclusion criteria

* Written consent of parent * Newborns over 35 weeks of amenorrhoea hospitalized in the maternity ward

Exclusion criteria

* person not affiliated to a health insurance scheme * Sepsis * Ductal dependent heart disease * Neurological impairment (anoxoischemic encephalopathy Sarnat\>1, pH\<7 and/or lactates\>11, meningitis) * Obstetrical trauma (instrumental delivery by forceps, vacuum cup or spatulas) * Potentially lethal malformation * Anemia (hemoglobin\<14g/dl) * Polyglobulia (hemoglobin\>22g/dl) * Small for gestational age (weight\<10th percentile) * Large for gestational age (weight\>97th percentile) * Proven gestational diabetes (non-insulin-dependent and insulin-dependent) * Maternal medical treatment (cardiac or anti-epileptic) * Inadequate parent understanding

Design outcomes

Primary

Measure	Time frame
Right and left average velocity of the cerebral artery	Change from birth to 48 hours of life

Countries

France

Outcome results

None listed

Source: ClinicalTrials.gov · Data processed: Feb 4, 2026