Fluid Loss
Conditions
Brief summary
Previous studies have shown that a positive fluid balance was an independent factor of worse prognosis in ICU patients with acute respiratory distress syndrome (ARDS), and negative fluid balance has been demonstrated to increase oxygenation index, reduce time under mechanical ventilation and ICU length of stay with no noticeable adverse effects. But there is no evidence that faster speed of negative fluid balance would be more beneficial for ARDS patients. So researchers designed the study to prove the effect of negatively fluid balancing speed for ICU patients with ARDS.
Interventions
OTHERtraditional speed
ARDS patients are performed negative fluid balance strategy with intravenous furosemide (4mg/h) or continuous veno-venous hemofiltration. The target amount of every day's net negative fluid balance for the first three days is 1000mL.Termination of the strategy is performed when mean arterial pressure drops below 65mmHg or perfusion index drops below 0.82 or lactate increases above 2mmol/L or acute kidney injury occurs.
OTHERfaster speed
ARDS patients are performed negative fluid balance strategy with intravenous furosemide (4mg/h) or continuous veno-venous hemofiltration. The target amount of every day's net negative fluid balance for the first three days is 1500mL.Termination of the strategy is performed when mean arterial pressure drops below 65mmHg or perfusion index drops below 0.82 or lactate increases above 2mmol/L or acute kidney injury occurs.
Sponsors
Qingdao University
Study design
Allocation
RANDOMIZED
Intervention model
PARALLEL
Primary purpose
TREATMENT
Masking
NONE
Eligibility
Sex/Gender
ALL
Age
18 Years to No maximum
Healthy volunteers
No
Inclusion criteria
·Patients with ARDS (Berlin 2012 criterion）
Exclusion criteria
* Pregnant women * Unstable hemodynamics status * \< 18 years old
Design outcomes
Primary
| Measure | Time frame | Description |
|---|---|---|
| increased oxygenation index proportion at 24h | at the time of 24 hours | Oxygenation index equals arterial oxygen partial pressure/fraction of inspiration O2 (PO2/FIO2). Increased oxygenation index proportion at 24h equals (oxygenation index at 24h - oxygenation index at baseline)/ oxygenation index at baseline. |
Secondary
| Measure | Time frame | Description |
|---|---|---|
| Oxygenation index every day | up to 7 days | oxygenation index equals arterial oxygen partial pressure/fraction of inspiration O2 (PO2/FIO2). |
| Duration of free mechanical ventilation | up to 28 days | Days when patients are free of mechanical ventilation |
| mortality | up to 28 days | a measure for the rate at which deaths occur in a given population |
Countries
China
Contacts
Primary ContactBo Yao, PHD
Outcome results
None listed