Cystoid Macular Edema After Phacoemulsification
Conditions
Brief summary
The aim of the study is determining the prophylactic effect of ketorolac tromethamine drop 0.5% eye drop on the functional and anatomical ocular characteristics of the diabetic patients after the phacoemulsification surgery. Cystoid macular edema (CME) is a ocular disease which the retinal thickness is increased by 30 % incidence at least or the visual acuity is decreased to 20/40 according to clinical definition. Ketorolac tromethamine is an non steroidal anti inflammatory medication which is used for treatment and Prophylactic for CME. Teh aim of this study is prophylactic effect of ketorolac tromethamine on choroidal and retinal thickness after Phacoemulsification in Diabetic Patients. In this randomized clinical trial, 102 eyes of 102 diabetic patients were included. All patients were undergone phacoemulsification surgery at Torfeh Eye Hospital between September 2015 and January 2017. To evaluate the prophylactic effect of ketorolac tromethamine topical eye drop, all cases were asked to apply it one day before the s:surgery in each 8 hours and continue it for 4 weeks after the surgery. Controls were not received placebo. All study population were examined using Snellen visual acuity chart, enhanced depth imaging optical coherence tomography (EDI-OCT). All patients were followed at 6, 12 and 24 weeks after the cataract surgery.
Interventions
DRUGusing of Ketorolac Tromethamine Eye Drop
using of Ketorolac Tromethamine Eye Drop one day before the surgery in each 8 hours and continue it for 4 weeks after the surgery
Sponsors
Shahid Beheshti University of Medical Sciences
Study design
Allocation
RANDOMIZED
Intervention model
PARALLEL
Primary purpose
PREVENTION
Masking
DOUBLE (Subject, Caregiver)
Eligibility
Sex/Gender
ALL
Age
20 Years to 95 Years
Healthy volunteers
Yes
Inclusion criteria
* Diabetic patients (type II) with cataract * Eligible patients at age range of 20 to 95 years old
Exclusion criteria
* Cases with a diabetic macular edema * proliferative diabetic retinopathy * history of intravitreal injection of bevacizumab and macular photocoagulation prior three months to the cataract surgery * glaucoma * refractive errors of more than ±6 diopters * history of previous ocular surgery * ocular pathological disorders * history of systemic diseases * history of medications which have a side effect on the retinal thickness * patients with a follow up of less than 6 months * individuals with any intraoperative complications will be excluded from this study.
Design outcomes
Primary
| Measure | Time frame | Description |
|---|---|---|
| Best Corrected visual acuity | 24 weeks after the surgery | Snellen visual acuity chart |
Secondary
| Measure | Time frame | Description |
|---|---|---|
| retinal and choroidal thickness | 24 weeks after the surgery | enhanced depth imaging optical coherence tomography (EDI-OCT) |
Countries
Iran
Contacts
Primary ContactHossien Mohammad Rabie, MD
Outcome results
None listed