Gastroenteritis
Conditions
Keywords
Gastroenteritis, panel by PCR, antibiotic use
Brief summary
Evaluation of the impact of the introduction of multiplex PCR panels on the clinical management of patients with gastroenteritis at the University Hospital of Lausanne, Switzerland.
Detailed description
Gastrointestinal multiplex PCR panels have been introduced in clinical practice several years ago, but the impact on the management of patients is yet unknown. The investigators are interested to evaluate if the multiplex PCR panels introduced at the University Hospital of Lausanne in July 2017 modified the usual medical care and in particular the prescription of anti-infectious treatments. The high sensitivity of the multiplex PCR panels should allow a more precise diagnosis of the etiology of the gastrointestinal symptoms of the patients than the traditional methods of stool culture and microscopy. The investigators expect therefore to observe a modification of the proportion of patients receiving anti-infectious treatment, but it is uncertain if it will lead to an increase or a decrease in the use of antibiotics. On one hand antibiotics could be prescribed more often due to a greater and faster detection of enteropathogens. On the other hand antibiotics could be prescribed less often due to more precise diagnosis, showing that viruses and certain bacteria do not require antibiotic treatment.
Interventions
DIAGNOSTIC_TESTGastro-intestinal panel by PCR
The study will evaluate the change in medical management with the replacement of traditional stool investigations (microscopy and culture) by the new gastrointestinal multiplex PCR panels
Sponsors
University of Lausanne Hospitals
Study design
Observational model
CASE_ONLY
Time perspective
RETROSPECTIVE
Eligibility
Sex/Gender
ALL
Age
18 Years to 100 Years
Healthy volunteers
No
Inclusion criteria
Ambulatory patients who consulted the University Hospital of Lausanne between July 2016 and May 2017, and were investigated by traditional methods (stool microscopy and culture). Ambulatory patients who consulted the University Hospital of Lausanne between July 2017 and May 2018 and had stool investigations by a gastro-intestinal panel.
Exclusion criteria
Patients for whom there ia record in the file that they do not accept that their data are used for research purposes.
Design outcomes
Primary
| Measure | Time frame | Description |
|---|---|---|
| Prescription of antibiotics | Within 1 week of availability of stool result | Number of patients receiving a prescription of antibiotics depending on the type of investigation |
Secondary
| Measure | Time frame | Description |
|---|---|---|
| Pathogens identified | 1 day | Number and types of pathogens identified depending on the type of investigation |
| Number of PCR tests requested. | 1 month | Number of patients for whom one, two or more PCR tests were requested. |
| Additional investigations | 1 week | Number of patients who underwent additional investigations within 1 week after reception of the results of the initial investigations |
Countries
Switzerland
Outcome results
None listed