Depression Disorder, Healthy
Conditions
Keywords
depression, self-referential, neural representation
Brief summary
To be aware of oneself as a unique entity in the world occurs early in human development and is the prerequisite of normal social functioning. The disturbance of self representation characterizes a variety of mental disorders such as autism and schizophrenia. Negative self-bias was found to serve as the core cognitive mechanism of depression disorder. However, there was no evidence to show the reason lead to negative bias. In the current study, investigators hypothesized that the blurring self representation was the neural correlates in depression disorder.
Detailed description
To test investigators' hypothesis, investigators adopted the self-referential task and fMRI to investigate the neural representation of self in depression patients, and compared with healthy control.
Interventions
None listed
Sponsors
Peking University
Southwest Medical University
Beijing Normal University
Study design
Observational model
COHORT
Time perspective
CROSS_SECTIONAL
Eligibility
Sex/Gender
ALL
Age
18 Years to 60 Years
Healthy volunteers
Yes
Inclusion criteria
* Patients should be clinical diagnosis of major depression disorder. * Healthy control participants should be age-matched with depression group, and should have no history of neurological or psychiatric diagnoses
Exclusion criteria
* Patients who also have bipolar disorder, schizophrenia, anxiety disorder * Healthy controls who have history of mental disorders
Design outcomes
Primary
| Measure | Time frame | Description |
|---|---|---|
| Neural representation of self | through study completion, an average of 2 year | We adopted the self referential task. In the task, participants were asked to judge whether a given word was appropriate to describe oneself (self-judgement condition), a celebrity (other-judgement condition) by pressing one of the two buttons with the index or middle finger. For judgments of each target person (i.e, self and celebrity), there were 3 categories of words describing the mental (personality traits, such as hard-working, friendly), physical (physical attributes, such as black hair, big eyes) and social (social roles, such as student, American) dimension of person knowledge. The fMRI task contained 6 runs, with 4.6 minutes per run. This paradigm and task allowed us to investigated the neural representation of self by comparing the BOLD activity under self-judgement condition with BOLD activity under other-judgement condition. |
Outcome results
None listed