Energy Metabolism for the Patients With Pulmonary Mycobacterium Avium Complex

Status

Completed

Phases

Unknown

Study type

Observational

Source

ClinicalTrials.gov

Registry ID

NCT03550820

Enrollment

105

Registered

2018-06-08

Start date

2018-05-01

Completion date

2021-12-27

Last updated

2021-12-28

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Emaciation, Energy Metabolism, Pulmonary MAC

Keywords

pulmonary MAC, energy metabolism

Brief summary

We aim to examine energy metabolism in patients with pulmonary MAC and clarify the causes of emaciation. We will also investigate the following: the relation between energy metabolism and degree of pulmonary MAC progression; relations among hospitalization, mortality rate, and time-course of changes in energy metabolism; and factors that affect energy metabolism.

Detailed description

Patients with pulmonary MAC with a lower BMI than healthy individuals also have a significantly poorer prognosis than those of normal weight. Emaciation in such patients is thought to be caused by destruction of lung structure from disease progression and an increased resting metabolic rate caused by the increased load from breathing; however, causes of emaciation and details of energy metabolism in these patients have not been studied. Elucidating details of energy metabolism and causes of emaciation in patients with pulmonary MAC could provide the basis for improvement in nutritional status and activities of daily living through early nutrition therapy and rehabilitation. We propose to clarify the following: Energy metabolism in patients with pulmonary MAC, including resting metabolic rate, calorie intake and consumption, and hormonal secretions. Relation between energy metabolism and degree of pulmonary MAC progression.

Interventions

None listed

Study design

Observational model

CASE_ONLY

Time perspective

PROSPECTIVE

Eligibility

Sex/Gender

ALL

Age

20 Years to 80 Years

Healthy volunteers

Inclusion criteria

* Subjects with pulmonary MAC.

Exclusion criteria

* Subjects with severe cardiovascular disease, diabetes, neurological disease, renal failure, endocrine disease and malignant neoplasm.

Design outcomes

Primary

Measure	Time frame
Relation between energy balance and pulmonary MAC severity	Three years

Secondary

Measure	Time frame
Relation between inflammation (CRP et.) and pulmonary MAC severity	Three years
Relation between bone mineral density and pulmonary MAC severity	Three years
Relation between hormone secretion and pulmonary MAC severity	Three years
Relation between pulmonary function and pulmonary MAC severity	Three years

Countries

Japan

Outcome results