Critical Illness, ICU Acquired Weakness
Conditions
Keywords
Diaphragmatic dysfunction, Mechanical Ventilation, ICU acquired weakness, Weaning, Skeletal muscles, Respiratory muscles
Brief summary
Critical illness is associated with ICU acquired weakness and diaphragmatic dysfunction. Ultrasound can evaluate the muscle mass non invasively and provides the ability for a muscle follow up during and after the ICU stay. Magnetic stimulation of the phrenic nerves and the measure of the end expiratory tracheal pressure with an occlusion valve allows to evaluate the diaphragm force production in mechanically ventilated patients. The aim of the present study is to constitute an image bank and to describe the muscle mass and function recovery in critically ill patients.
Detailed description
Critical illness is associated with ICU acquired weakness and diaphragmatic dysfunction. Ultrasound can evaluate the muscle mass non invasively and provides the ability for a muscle follow up during and after the ICU stay. Magnetic stimulation of the phrenic nerves and the measure of the end expiratory tracheal pressure with an occlusion valve allows to evaluate the diaphragm force production in mechanically ventilated patients. The aim of the present study is to constitute an image bank and to describe the mass and function recovery in critically ill patients. Ultrasound and clinical data will be collected and analysed during the ICU stay.
Interventions
None listed
Sponsors
University Hospital, Montpellier
Study design
Observational model
COHORT
Time perspective
PROSPECTIVE
Eligibility
Sex/Gender
ALL
Age
18 Years to No maximum
Healthy volunteers
No
Inclusion criteria
* Critically ill patients with at least one organ failure defined, organ failure being defined by a SOFA equal or above 3 for the organ, and an expected duration of ICU stay equal of above 3 days
Exclusion criteria
\- Pregnancy, age below 18, absence of consent
Design outcomes
Primary
| Measure | Time frame | Description |
|---|---|---|
| Ultrasound characteristics of the quadriceps | Since admission at day 0 and measured repetitively by 48 hours untildischarge from ICU or date of death from any cause, whichever came first, assessed up to day 28 | Changes in ultrasound characteristics of the quadriceps : cross sectional area of quadriceps (cm2) |
Other
| Measure | Time frame | Description |
|---|---|---|
| Ultrasound characteristics of the biceps | Since admission at day 0 and measured repetitively by 48 hours untildischarge from ICU or date of death from any cause, whichever came first, assessed up to day 28 | Changes in ultrasound characteristics of the biceps : thickness of the biceps (mm) |
| Ultrasound characteristics of the diaphragm | Since admission at day 0 and measured repetitively by 48 hours untildischarge from ICU or date of death from any cause, whichever came first, assessed up to day 28 | Ultrasound characteristics of the diaphragm : thickness (mm) |
Countries
France
Outcome results
None listed