Pilot Study of Myocardial Effects Following an Endurance Race

A Pilot Study of the Myocardial Effects of an Endurance Race as Evaluated by Computer Tomography

Status

UNKNOWN

Phases

Study type

Interventional

Source

ClinicalTrials.gov

Registry ID

NCT03549364

Enrollment

Registered

2018-06-08

Start date

2018-05-24

Completion date

2019-12-31

Last updated

2019-04-24

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Myocardial Blood Flow

Brief summary

Ten healthy subjects perform a baseline computer tomography (CT) of the heart and routine laboratory blood tests for myocardial injury and inflammation. The same data are collected \<24 hours after an endurance race corresponding to a maraton run (i.e. about 40 km of running and/or about 2.5 hours hard training or more). A third collection of lab tests and CT is done a couple of weeks after the race. Magnetic resonance imaging is also performed in parallell to the CT on occasions 2 and 3 in most subjects, serving as a reference for determination of myocardial blood flow.

Detailed description

Ten healthy subjects perform a baseline computer tomography (CT) of the heart and routine laboratory blood tests (troponin T, hs-CRP, CK-mb etc) for myocardial injury and inflammation. The same data are collected \<24 hours after an endurance race corresponding to a maraton run (i.e. about 40 km of running and/or about 2.5 hours hard training or more). A third collection of lab tests and CT is done a couple of weeks after the race. Magnetic resonance imaging (MRI) is also performed in parallell to the CT on occasions 2 and 3 in most subjects, serving as a reference for determination of myocardial blood flow. The CT of the heart includes contrast injection and blood flow will be determined by a recently developed based on very powerful computers using machine learning.

Interventions

BEHAVIORALEndurance Race

1 CT and lab tests, 2 CT and lab tests within 24h of a race, 3 follow up investigations 1-2 weeks after the race with CT and lab tests

Study design

Allocation

Intervention model

SINGLE_GROUP

Primary purpose

DIAGNOSTIC

Masking

NONE

Eligibility

Sex/Gender

ALL

Age

18 Years to No maximum

Healthy volunteers

Yes

Inclusion criteria

Healthy subjects, experienced in long distance running

Exclusion criteria

Significant renal, kidney, heart, liver or musculoskeletal disease.

Design outcomes

Primary

Measure	Time frame	Description
Change in myocardial blood flow by the race?	All investigations are performed < 2 months	Detection of potential differences in blood flow between occasion 1 and 2 and 3

Countries

Sweden

Contacts

Primary ContactFredrik H Nyström, MD PhD Professor

fredrik.h.nystrom@gmail.com0736569303

Outcome results

None listed

Source: ClinicalTrials.gov · Data processed: Feb 4, 2026