Papillomavirus Infections
Conditions
Brief summary
Since other genital infections enhance HIV susceptibility by inducing inflammation, the investigators study the relationship between the vaginal microbiota composition and the risk of HPV infection, cervical cytological abnormalities.
Detailed description
Persistent infection with oncogenic Human Papillomavirus (HPV) is necessary but not sufficient for the development of cervical cancer. Additional factors correlated with HPV persistence include immunodeficiency caused by HIV, smoking, use of oral contraceptives and, more recently reported, vaginal dysbiosis. In a state of dysbiosis, there is a marked reduction of Lactobacillus and a high diversity of bacteria, with increased abundance of anaerobic bacterial species. Based on this, the investigators are going to analyze the changes of microbiota in women with high-risk HPV and the cervical lesions. And the investigators hope to figure out the difference and change in microbiota to realize the tanning of cervical lesions.
Interventions
BIOLOGICALHuman Papillomavirus
women with high-risk Human Papillomavirus or not
Sponsors
Peking Union Medical College Hospital
Study design
Observational model
CASE_CONTROL
Time perspective
PROSPECTIVE
Eligibility
Sex/Gender
FEMALE
Age
25 Years to 50 Years
Healthy volunteers
Yes
Inclusion criteria
Clinical diagnosis of HR-HPV results.
Exclusion criteria
Clinical diagnosis of vaginitis, immune disease, malignancy History of cervical lesions Pregnancy Clinical diagnosis of other serious systemic primary diseases, such as severe liver and kidney dysfunction Severe mental illness
Design outcomes
Primary
| Measure | Time frame | Description |
|---|---|---|
| Vaginal microbiota and HR-HPV infection | 12 months | The persistence vaginal organism in HPV infection participants |
| Vaginal microbiota and the cervical lesion | 12 to 36 months | The cervical cytology, HPV and the vaginal microbiota were evaluated |
Countries
China
Outcome results
None listed