Bone Density, Dental Caries, Dental Fluoroses
Conditions
Keywords
fluoride, genetics, physical activity, diet
Brief summary
A cohort of newborns was recruited for the Iowa Fluoride Study from 1992-95 to assess the complex relationships among fluoride intakes, fluoride exposures, dental fluorosis, and dental caries. Detailed questionnaires were sent every 1.5-6 months concerning water sources, fluoride exposures, dietary intakes, etc. Standardized dental exams were conducted at \ ages 5, 9, 13, 17, and 23. At about age 5, participants were invited to join the offshoot Iowa Bone Development Study. Bone densitometry assessments were conducted at ages 5, 8, 11, 13, 15, 17, 19, and 23. These included Dual-energy X-ray Absorptiometry (DXA) of hip, lumbar spine, and whole body from age 5; peripheral Quantitative Computed Tomography (pQCT) of the radius and tibia from age 11; and Multi-Detector Computed Tomography (MDCT) of the tibia from age 19. Physical activity and other factors also were assessed longitudinally.
Detailed description
A cohort of newborns was recruited for the Iowa Fluoride Study from 1992-95 to assess the complex relationships among fluoride intakes, fluoride exposures, dental fluorosis, and dental caries. Detailed questionnaires were sent every 1.5-6 months concerning water sources, fluoride exposures, dietary intakes, etc. Standardized dental exams were conducted at \ ages 5, 9, 13, 17, and 23. At about age 5, participants were invited to join the offshoot Iowa Bone Development Study. Bone densitometry assessments were conducted at ages 5, 8, 11, 13, 15, 17, 19, and 23. These included Dual-energy X-ray Absorptiometry (DXA) of hip, lumbar spine, and whole body from age 5; peripheral Quantitative Computed Tomography (pQCT) of the radius and tibia from age 11; and Multi-Detector Computed Tomography (MDCT) of the tibia from age 19. Physical activity and other factors also were assessed longitudinally.
Interventions
None listed
Sponsors
Steven M Levy
Study design
Observational model
COHORT
Time perspective
PROSPECTIVE
Eligibility
Sex/Gender
ALL
Age
1 Months to 30 Years
Healthy volunteers
Yes
Inclusion criteria
* healthy newborn
Exclusion criteria
* not health newborn
Design outcomes
Primary
| Measure | Time frame | Description |
|---|---|---|
| dental fluorosis-5 | age 5 | dental fluorosis exam results |
| dental fluorosis-9 | age 9 | dental fluorosis exam results |
| dental fluorosis-13 | age 13 | dental fluorosis exam results |
| dental fluorosis-17 | age 17 | dental fluorosis exam results |
| dental fluorosis-23 | age 23 | dental fluorosis exam results |
| dental caries-5 | age 5 | dental caries exam results |
| dental caries-9 | age 5 | dental caries exam results |
| dental caries-13 | age 9 | dental caries exam results |
| dental caries-17 | age 17 | dental caries exam results |
| dental caries-23 | age 23 | dental caries exam results |
| bone densitometry-5 | age 5 | DXA scans |
| bone densitometry-8 | age 8 | DXA scans |
| bone densitometry-11 | age 11 | DXA and pQCT scans |
| bone densitometry-13 | age 13 | DXA and pQCT scans |
| bone densitometry-15 | age 15 | DXA and pQCT scans |
| bone densitometry-17 | age 17 | DXA and pQCT scans |
| bone densitometry-19 | age 19 | DXA, pQCT, and MDCT scans |
| bone densitometry-23 | age 23 | DXA, pQCT, and MDCT scans |
Outcome results
None listed