Effect of Cherry Concentrate on Brain Activation and Perfusion in Healthy Older Adults

Status

Completed

Phases

Study type

Interventional

Source

ClinicalTrials.gov

Registry ID

NCT03547102

Enrollment

Registered

2018-06-06

Start date

2016-01-31

Completion date

2016-12-31

Last updated

2018-06-26

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Healthy

Brief summary

Effect of 8 weeks of cherry concentrate supplementation on cognitive function and brain perfusion in healthy older adults

Detailed description

The investigators will perform a double blind, randomised controlled study to determine whether cherry polyphenols improve peripheral vascular function and cerebral perfusion resulting in improved task related brain activation and cognitive function. 30 healthy elderly men and women 60-85y years will be recruited to complete 8-week supplementation with MC concentrate or an isoenergetic cherry placebo concentrate. Participants will be pair matched for age, sex, and cognitive function (Adenbrooke's Cognitive Examination III, ACE-III) and then randomised using a sealed envelope system to receive either placebo or cherry.

Interventions

DIETARY_SUPPLEMENTCherry concentrate

DIETARY_SUPPLEMENTPlacebo concentrate

Study design

Allocation

RANDOMIZED

Intervention model

PARALLEL

Primary purpose

BASIC_SCIENCE

Masking

TRIPLE (Subject, Investigator, Outcomes Assessor)

Eligibility

Sex/Gender

ALL

Age

60 Years to 80 Years

Healthy volunteers

Yes

Inclusion criteria

* physically inactive consuming 5 or less portions of fruit per day Addenbrookes cognitive examination III score \>88

Exclusion criteria

* physically active consuming more than 5 portions of fruit per day Addenbrookes cognitive examination III score \<88 Contraindications for MRI

Design outcomes

Primary

Measure	Time frame	Description
Brain perfusion	Change from baseline to 8 weeks supplementation	Arterial spin labelling using MRI, measure will be reported as ml/min

Secondary

Measure	Time frame	Description
Cognitive function	Change from baseline to 8 weeks supplementation	Battery of cognitive function tasks assessing executive function, global cognitive function score will be reported
Brain activation (fMRI)	Change from baseline to 8 weeks supplementation	fMRI using a hippocampal biased task
Plasma nitrite concentration	Change from baseline to 8 weeks supplementation	Plasma sample analysed via chemiluminescence technique

Outcome results

None listed

Source: ClinicalTrials.gov · Data processed: Feb 4, 2026