Epidermoid Cancer Development in Esophageal Achalasia

Incidence and Risk Factors for Development of Epidermoid Carcinoma in Esophageal Achalasia

Status

UNKNOWN

Phases

Unknown

Study type

Observational

Source

ClinicalTrials.gov

Registry ID

NCT03546998

Enrollment

681

Registered

2018-06-06

Start date

1973-01-01

Completion date

2025-12-31

Last updated

2018-06-06

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Achalasia, Epidermoid Carcinoma

Keywords

epidermoid carcinoma, esophageal achalasia, risk factors

Brief summary

Esophageal achalasia is a precancerous condition for epidermoid carcinoma; incidence and risk factors for cancer development are not defined. Incidence and risk factors for epidermoid carcinoma development in achalasia patients were investigated.

Detailed description

In order to define incidence and risk factors for epidermoid carcinoma 681 patients affected by esophageal achalasia observed since 1973 were followed up with no time limits according to a prospective follow-up protocol. The local institutional review board approved using the database from the division of thoracic surgery for research purposes. Clinical, radiological and endoscopic data of achalasia patients were collected and analyzed.

Interventions

DIAGNOSTIC_TESTClinical instrumental examinations

Achalasia patients were periodically submitted to clinical assessment, barium swallow (esophageal diameter and residual barium column were measured), endoscopy. Mucosal esophageal biopsies were taken in order to diagnose dysplasia or epidermoid carcinoma.

Study design

Observational model

COHORT

Time perspective

PROSPECTIVE

Eligibility

Sex/Gender

ALL

Healthy volunteers

Inclusion criteria

* diagnosis of primary esophageal achalasia achieved by means of radiology, endoscopy and manometry

Exclusion criteria

* pseudoachalasia

Design outcomes

Primary

Measure	Time frame	Description
Detection of epidermoid carcinoma of the esophagus	1 year	Detection of epidermoid carcinoma of the esophagus by means of upper GI endoscopy

Secondary

Measure	Time frame	Description
Result of achalasia treatment by investigating dysphagia and gastro-esophageal reflux	1 year	Result of achalasia treatment assessed by means of semiquantitative grading scales of dysphagia and gastro-esophageal reflux

Countries

Italy

Contacts

Primary ContactSandro Mattioli, MD

sandro.mattioli@unibo.it0039 0512144643

Backup ContactMarisaluisa Lugaresi, MD

marialuisa.lugaresi2@unibo.it3356843779

Outcome results

None listed

Source: ClinicalTrials.gov · Data processed: Feb 4, 2026