Cannabis
Conditions
Keywords
Cannabis
Brief summary
This is a double-blind within-subjects clinical laboratory study comparing the product appeal and abuse liability-related subjective effects of different flavored cigar wrappers for marijuana blunts.
Interventions
DRUGMarijuana
Marijuana smoked via blunts with different cigar wrappers
Sponsors
Battelle Memorial Institute
Study design
Allocation
RANDOMIZED
Intervention model
CROSSOVER
Primary purpose
BASIC_SCIENCE
Masking
TRIPLE (Subject, Investigator, Outcomes Assessor)
Eligibility
Sex/Gender
ALL
Age
18 Years to 55 Years
Healthy volunteers
Yes
Inclusion criteria
* Currently living in Baltimore City or Baltimore County, MD; * Able to read, understand, and sign informed consent; * 18-55 years old; * Currently smokes marijuana blunts; * Designation of Medically Healthy for Research by the Study Physician; and * Willing to abstain from illicit drug use other than marijuana for the duration of the study.
Exclusion criteria
* BAC \> 0.020% as measured by alcohol breathalyzer; * Meets DSM-5 criteria for severe current or lifetime Cannabis Use Disorder; * Meets DSM-5 criteria for any current Axis I disorder, other than current mild or moderate Cannabis Use Disorder; * Self-reported current desire to stop marijuana use; * Self-reported current asthma, chronic obstructive pulmonary disease, hypertension, cardiovascular disease or any other medical illness that precludes participation; * Has difficulties with blood draws or poor venous access; * History of blood donation in the past 30 days or receiving blood products within the past 2 months prior to any experimental visit; * Among females, current pregnancy or lactation or attempting to get pregnant, or at risk of becoming pregnant; * Acute illness which will require participant to be rescheduled
Design outcomes
Primary
| Measure | Time frame | Description |
|---|---|---|
| Puff topography | During marijuana blunt smoking | Total inhalation volume |
Secondary
| Measure | Time frame | Description |
|---|---|---|
| Carbon monoxide | Immediately after marijuana blunt smoking | Exhaled breath carbon monoxide (ppm) |
| Subjective drug effects | Immediately after marijuana blunt smoking | Ratings of good and high |
| Measures of demand | Immediately after marijuana blunt smoking | Number of units an individual would purchase at varying price points |
Countries
United States
Outcome results
None listed