Bronchopulmonary Dysplasia, Premature Infant
Conditions
Brief summary
SpO2 instability is in the nature of premature infants. Hypoxic episodes occur spontaneously in many of these infants, especially after the first week of life. Different interventions have been shown to influence the incidence of hypoxemic episodes in premature infants. A few studies point towards potential clinical benefits of better oxygenation and less hypoxic events by positioning very low birth weight infants prone, though a recent meta-analysis didn't find a clear benefit of prone position. The aim of this study is to evaluate the changes in oxygenation among preterm infants receiving respiratory support when positioned prone versus supine, as documented by SpO2 histograms.
Interventions
PROCEDUREPosition change
Each subject will serve as his or her own control. Half of the infants will be placed supine for 3 hours, followed by 3 hours of prone positioning and back to supine for 3 hours and the other half will be start in prone position with consecutive periods of supine and then prone
Sponsors
Rambam Health Care Campus
Study design
Allocation
RANDOMIZED
Intervention model
CROSSOVER
Primary purpose
SUPPORTIVE_CARE
Masking
NONE
Eligibility
Sex/Gender
ALL
Age
14 Days to No maximum
Healthy volunteers
No
Inclusion criteria
Premature infants with a weight \< 1500 g who are receiving respiratory support
Exclusion criteria
Congenital anomalies, acute lung pathology for example x-ray confirmed pneumonia, air leak, active culture proven sepsis or on inotropic support for low blood pressure.
Design outcomes
Primary
| Measure | Time frame | Description |
|---|---|---|
| Oxygenation instability | 3 hours in each position | SPO2 histogram documents the oxygenation stability. we will record the histogram at the end of each period of time and compare it |
Countries
Israel
Outcome results
None listed