Pediatric Retinoblastoma, Retinoblastoma
Conditions
Keywords
18-126, Memorial Sloan Kettering Cancer Center
Brief summary
The purpose of this study is to see if there is a difference between the development of the brain (neurodevelopment) in children who have been treated for retinoblastoma with multiple anesthetic exposures, compared with brain development in children who have never had anesthesia.
Interventions
Measures dexterity
the WISC-V assessment produces a Full Scale IQ (FSIQ) used for primary power consideration in this study. The FSIQ is the most comprehensive global ability score on the WISC-V, and it has been conventionally reported and interpreted as an estimation of overall intellectual ability
OTHERCalifornia Verbal Learning Test, Children's Version
Used to assess verbal learning and memory in children and adolescents
OTHERBeery Developmental Test of Visual Motor Integration, 6th edition
Helps assess visual-motor skills in children and adults.
OTHERBehavior Assessment System for Children/Parent Report
The Behavior Assessment System for Children/Parent Report is a questionnaire that assesses the social-emotional and behavioral functioning (e.g., anxiety, depression, attention, hyperactivity, adaptability, leadership, social skills, etc.) in children between the ages of 2 and 22 years, and is available in English and Spanish.
Sponsors
Memorial Sloan Kettering Cancer Center
Study design
Observational model
COHORT
Time perspective
PROSPECTIVE
Eligibility
Sex/Gender
ALL
Age
6 Years to 17 Years
Healthy volunteers
No
Inclusion criteria
* Age ≥ 6 and \< 17 years old
Exclusion criteria
* Diagnosis of any secondary disease associated with developmental delay * History of second cancer diagnosis * Legal Blindness * Past surgery of any type, with the exception of enucleation for retinoblastoma * Past exposure to anesthesia for surgical intervention * More than one anesthesia encounter for surgical intervention before diagnosis at MSK * Past External Beam Radiation for treatment of retinoblastoma * Past systemic chemotherapy * Non-native speaker of English; however, children whose parents speak only Spanish will be included, because the tests for parents are available in Spanish
Design outcomes
Primary
| Measure | Time frame | Description |
|---|---|---|
| Comparing scores in neuropsychological testing results | 6 weeks | The primary outcome is based on the Wechsler Intelligence Scale for Children, 5th edition (WISC-V) measured at follow up. The 5 primary index scores on the WISC-V (Verbal Comprehension, Visual Spatial, Fluid Reasoning, Working Memory, and Processing Speed) are based on 10 subtests and represent intellectual functioning in different cognitive areas. Similar to the FSIQ, the primary index scores are on a standard score metric with a mean of 100 (SD=15). The WISC-V consists of 16 subtests; each subtest is based on a scaled score metric with a mean of 10 and standard deviation (SD) of 3. Performance on these domain-specific subtests will be summarized and analyzed similarly to the FSIQ. |
Countries
United States
Contacts
Primary ContactVittoria Arslan Carlon, MD
Backup ContactDavid Abramson, MD
Outcome results
None listed