Spinal Cord Injuries
Conditions
Keywords
postprandial, glycemia, lipemia, macronutrient metabolism, physical activity
Brief summary
This study investigates the effect of various forms of upper extremity exercise on postprandial glycemia and lipemia in persons with spinal cord injury (SCI). Participants are measured at rest and fed a standardized meal following seated rest (CON), moderate intensity continuous arm cycling (MICT), high intensity interval arm cycling (HIIT), and circuit resistance exercise (CRT) matched for exercise energy expenditure.
Interventions
BEHAVIORALSeated control (CON)
Seated rest
BEHAVIORALModerate intensity continuous (MICT)
Arm cycling at a continuous power output
BEHAVIORALHigh intensity interval training (HIIT)
Arm cycling at power outputs that vary between high and low intensity intervals
BEHAVIORALCircuit resistance training (CRT)
Alternating between six upper extremity resistance maneuvers interspersed with low-resistance/high-speed arm cycling.
OTHERLiquid Meal
A liquid meal consisting of 600 kcal comprised of 50% carbohydrate, 35% fat, and 15% protein (by kcal).
Sponsors
University of Miami
Study design
Allocation
RANDOMIZED
Intervention model
FACTORIAL
Primary purpose
PREVENTION
Masking
NONE
Intervention model description
Static first arm with randomized remaining three arms.
Eligibility
Sex/Gender
ALL
Age
18 Years to No maximum
Healthy volunteers
Yes
Inclusion criteria
* Adult (\>/=18 years of age) * Neurologically stable chronic (\>/= 1year) spinal cord injury (SCI) * American Spinal Injury Association Impairment Scale (AIS) grade A, B, or C * SCI at level \</= the first thoracic vertebrae (T1)
Exclusion criteria
* Being of ≤ 18 years of age. * Contraindication to exercise (ACSM Guideline, 10th edition) * Lower extremity fracture or dislocation within 6 months of participation, * History head injury or seizures. * Inability to consent. * Restrictions in upper extremity range of motion that would prevent an individual from achieving an unhindered arm cycling motion or moving throughout a range needed to perform resistance maneuvers. * A pressure ulcer at ischial/gluteus, trochanteric, sacral, or heel sites within the last 3 months. * Pregnancy determined by urine testing in sexually active females. * Imprisonment in state or federal jail or prison.
Design outcomes
Primary
| Measure | Time frame | Description |
|---|---|---|
| Postprandial insulin sensitivity | 2.5 hr | Measured by insulin incremental area under the curve (iAUC). |
Secondary
| Measure | Time frame | Description |
|---|---|---|
| Lipemia | 2.5 hr | Measured by blood concentrations of triglycerides. |
| Carbohydrate use | 2.5 hr | Whole-body rates of carbohydrate oxidation, as determined by open-circuit indirect calorimetry. |
| Fat use | 2.5 hr | Whole-body rates of fat oxidation, as determined by open-circuit indirect calorimetry. |
| Fasted insulin sensitivity | Baseline | Measured by HOMA-2 model. This model is calculated based on the ratio of blood glucose and insulin. |
Countries
United States
Outcome results
None listed