Type1diabetes
Conditions
Brief summary
Few people with type 1 diabetes achieve exercise guidelines and many programmes designed to increase physical activity have failed. High-intensity interval training (HIT) has been shown to be a time-efficient alternative to traditional moderate-intensity continuous training (MICT) in various groups without type 1 diabetes. A single bout of HIT does not increase the risk of hypoglycaemia in people with type 1 diabetes. This study aimed to assess whether HIT a safe, effective and time-efficient training strategy to improve cardio-metabolic health and reduce the risk of hypoglycaemia in people with type 1 diabetes.
Detailed description
This study aimed to investigate whether 1) six weeks of high-intensity interval training (HIT) induces similar improvements in cardio-metabolic health markers as moderate-intensity continuous training (MICT) in people with type 1 diabetes, and 2) whether HIT abolishes acute reductions in plasma glucose observed following MICT sessions. Fourteen sedentary individuals with type 1 diabetes (n=7 per group) completed six weeks of HIT or MICT 3 times per week. Pre- and post-training measurements were made of 24h interstitial glucose profiles (using continuous glucose monitors (CGMS)) and cardio-metabolic health markers (V ̇O2peak, blood lipid profile and aortic pulse wave velocity; aPWV). Capillary blood glucose concentrations were assessed before and after exercise sessions throughout the training programme to investigate changes in blood glucose during exercise in the fed state.
Interventions
Sponsors
Liverpool John Moores University
Study design
Allocation
NON_RANDOMIZED
Intervention model
PARALLEL
Primary purpose
BASIC_SCIENCE
Masking
NONE
Eligibility
Healthy volunteers
No
Inclusion criteria
* duration of type 1 diabetes \>6 months * basal bolus regimen * no significant history of hyper- or hypoglycaemia (determined from medical history)
Exclusion criteria
duration of type 1 diabetes \<6 months, * insulin pump therapy * significant history of hyper- or hypoglycaemia (determined from medical history) * obesity (BMI \>30 kg∙m-2) * pregnancy or planning pregnancy * uncontrolled hypertension (\>180/100 mmHg) * angina, autonomic neuropathy * taking any medication that affects heart rate * major surgery planned within 6 weeks of the study * severe nonproliferative * unstable proliferative retinopathy
Design outcomes
Primary
| Measure | Time frame | Description |
|---|---|---|
| Maximal aerobic capacity | change in baseline maximal aerobic capacity at 6 weeks | Maximal aerobic capacity test pre and post 6-week training intervention |
Secondary
| Measure | Time frame | Description |
|---|---|---|
| Vascular stiffness | change in baseline vascular stiffness at 6 weeks | Aortic pulse wave velocity to measure vascular stiffness |
Countries
United Kingdom
Outcome results
None listed