Heart Arrest, Targeted Temperature Management
Conditions
Brief summary
This study aims to examine the prognostic value of 18 channel amplitude-integrated EEG (aEEG) in comatose cardiac arrest patients The study design is a prospective observational study. Cardiac arrest patients undergoing targeted temperature management (TTM) will participate in the study. Relation of aEEG in each channel with the neurologic outcome at 6 month after return of spontaneous circulation (ROSC) will be evaluated.
Detailed description
Normal trace was defined as continuous cortical activity on the raw EEG scan; in addition, the upper margin of the aEEG scan, referred to as the aEEG maximum, was \>10 μ V, and the lower margin of the aEEG scan, referred to as the aEEG minimum, was \>5 μ V. The Time from ROSC to normal trace (TTNT, hours) is predictor of neurological outcome in these patients. We will evaluate the prognostic values of TTNTs in all aEEG channels.
Interventions
DIAGNOSTIC_TESTMulti-channel aEEG monitoring
18 channel aEEG monitoring in comatose TTM-treated patients
Sponsors
Sang Hoon Oh
Study design
Observational model
COHORT
Time perspective
PROSPECTIVE
Eligibility
Sex/Gender
ALL
Age
19 Years to No maximum
Healthy volunteers
No
Inclusion criteria
Comatose cardiac arrest TTM treatment Multi channel aEEG monitoring
Exclusion criteria
Cerebral origin cardiac arrest Known epilepsy
Design outcomes
Primary
| Measure | Time frame | Description |
|---|---|---|
| Time to normal trace in each aEEG channel | at day 180 | Normal trace was defined as continuous cortical activity on the raw EEG scan; in addition, the upper margin of the aEEG scan, referred to as the aEEG maximum, was \>10 μ V, and the lower margin of the aEEG scan, referred to as the aEEG minimum, was \>5 μ V. The Time from ROSC to normal trace (TTNT, hours) is predictor of neurological outcome in these patients. We will evaluate the prognostic values of TTNTs in all aEEG channels. |
Secondary
| Measure | Time frame | Description |
|---|---|---|
| TTNT threshold for neurologic prognostication in each aEEG channel | at day 180 | Using area under the curve (AUC) of each channel aEEG for neurological outcome, we will determine the best TTNT thresholds for good neurological outcome (CPC 1 to 2) in all aEEG channels. |
| Alpha delta ratio of each channel aEEG for good neurological outcome (CPC 1 to 2) | at day 180 | The percentage powers in the alpha, theta and delta bands and the ratio of the powers in different frequency bands (i.e., alpha/delta) will be calculated. Finally we will evaluate the prognostic values of these ratios of the different bands. |
| Comparison of prognostic value between aEEG and various predictors | at day 180 | We will compare the prognostic performances (i.e., sensitivity, specificity, AUC) for poor neurological outcome (CPC 3 to 5) between EEG and these predictors. |
Countries
South Korea
Outcome results
None listed