Effects of Kale Ingredients on Lipid Status Parameter
Conditions
Keywords
kale, antioxidant capacity, cholesterol, lipid status
Brief summary
This intervention study investigates the effects of various kale preparations (dietary supplements) on lipid status parameters. Within the study period of 8 weeks, three blood withdrawals are planned (week 0, 4 and 8) for the volunteers. Lipid status parameters (total cholesterol, HDL cholesterol, LDL cholesterol, triacylglycerides) will be determined in blood. There is a correlation between contents of LDL cholesterol, total cholesterol and triacylglycerides and the risk for cardiovascular diseases (CVD). In contrast, a high content of HDL cholesterol is correlated with a lower risk for CVD. In addition, the contents of apolipoprotein A1 and apolipoprotein B will be analysed.
Interventions
DIETARY_SUPPLEMENTKale Preparation Kale Powder
Effect of kale preparation kale powder on lipid status
DIETARY_SUPPLEMENTKale Preparation Kale Extract
Effect of kale preparation kale extract on lipid status
DIETARY_SUPPLEMENTKale Preparation Flavonoid Extract
Effect of kale preparation flavonoid extract on lipid status
DIETARY_SUPPLEMENTPlacebo
Effect of placebo on lipid status
Sponsors
University of Jena
Study design
Allocation
RANDOMIZED
Intervention model
PARALLEL
Primary purpose
PREVENTION
Masking
QUADRUPLE (Subject, Caregiver, Investigator, Outcomes Assessor)
Eligibility
Sex/Gender
FEMALE
Age
18 Years to No maximum
Healthy volunteers
Yes
Inclusion criteria
* total cholesterol \> 200 mg/dl
Exclusion criteria
* LDL cholesterol \< 130 mg/dl * medication to lower blood lipids * genetically based hypercholesterolemia
Design outcomes
Primary
| Measure | Time frame | Description |
|---|---|---|
| Change of lipid status parameters | weeks 0, 4 and 8 | total cholesterol, HDL cholesterol, LDL cholesterol |
Secondary
| Measure | Time frame | Description |
|---|---|---|
| Change of apolipoproteins | weeks 0, 4 and 8 | apolipoprotein A1 and apolipoprotein B |
| Change of antioxidant capacity | weeks 0, 4 and 8 | lipophilic antioxidant capacity (L-TEAC) |
Countries
Germany
Contacts
Primary ContactVolker Böhm, PD Dr.
Outcome results
None listed