Clinical & Radiographic Evaluation of Neo MTA Versus White MTA in Revascularization of Non-Vital Immature Permanent Teeth

Clinical and Radiographic Evaluation of Neo MTA Versus Conventional White MTA in Revascularization of Non-Vital Immature Permanent Anterior Teeth: A Randomized Controlled Trial

Status

UNKNOWN

Phases

Early Phase 1

Study type

Interventional

Source

ClinicalTrials.gov

Registry ID

NCT03545139

Enrollment

Registered

2018-06-04

Start date

2019-09-01

Completion date

2021-09-30

Last updated

2020-02-20

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Nonvital Tooth

Keywords

pulp revascularization, endodontic regeneration, NeoMTA

Brief summary

* To evaluate and compare the degree of tooth discoloration in tooth crowns induced by Neo MTA versus white MTA over time. * Evaluation of the effectiveness of Neo MTA as coronal plug in revascularization of immature teeth with necrotic pulp.

Detailed description

The new formulation of MTA (NeoMTA) does not contain bismuth oxide, will be used in revascularization of nonvital immature permanent anterior teeth. to evaluate the effectiveness of Neo MTA as coronal plug and compare the degree of tooth discoloration in tooth crowns induced by Neo MTA versus white MTA over time.

Interventions

BIOLOGICALNeoMTA nusmile

A new formulation of MTA was developed in which bismuth oxide was omitted.

BIOLOGICALWhite MTA

Revascularization with Conventional white mineral trioxide aggregate as coronal plug.

Study design

Allocation

RANDOMIZED

Intervention model

PARALLEL

Primary purpose

TREATMENT

Masking

DOUBLE (Subject, Outcomes Assessor)

Eligibility

Sex/Gender

ALL

Age

7 Years to 15 Years

Healthy volunteers

Inclusion criteria

* Age of patients: 7-15years old. * Free from any systemic diseases that may affect the normal healing process. * Tooth with immature root apex. * Traumatically or cariously exposed non vital permanent anterior tooth. * Pulp space not needed for post and core for final restoration. * Compliant patient/parent

Exclusion criteria

* Patients having allergy to medicaments and antibiotics necessary to complete procedure. * Tooth with vital pulp or complete root formation. * Teeth with internal or external root resorption. * Un-cooperative patients. * Luxative injuries. * Teeth with a root fracture * Alveolar fracture * Subjects with chronic systemic illness. * Subjects with poor oral hygiene. * Compromised remaining tooth structure as teeth with extensive loss of coronal tissue will require restoration with a post that will occupy the space required for blood clot formation.

Design outcomes

Primary

Measure	Time frame	Description
Discoloration/ Staining potential	9 month	Using spectrophotometer by operator

Secondary

Measure	Time frame	Description
Pain on biting	9 month	Verbal questioning of the patient
Pain on percussion	9 month	Using back of the mirror
Sinus or fistula, recurrent swelling	9 month	Visual examination by operator
Root lengthening	9 month	Radiographic Digora image analysis software i.e. Digora for windows software DFW

Countries

Egypt

Outcome results

None listed

Source: ClinicalTrials.gov · Data processed: Feb 4, 2026