Postoperative Complications, Respiratory Failure
Conditions
Brief summary
This study aims to investigate, with a case-crossover design, the effects of a short course of preventive CPAP administered in the immediate postoperative period in patients at high-risk of developing postoperative pulmonary complications undergoing major vascular surgery.
Interventions
DEVICEPostoperative preventive CPAP
Administration of a course of 2 hours of CPAP with 7.5 cmH2O pressure and 0.30 FIO2
Sponsors
University of Genova
Study design
Observational model
CASE_CROSSOVER
Time perspective
PROSPECTIVE
Eligibility
Sex/Gender
ALL
Age
18 Years to No maximum
Healthy volunteers
No
Inclusion criteria
* Open or endovascular surgery on the abdominal aorta * Surgical procedure requiring general anaesthesia and invasive intraoperative mechanical ventilation * Intermediate-high risk of postoperative pulmonary complications (ARISCAT score ≥ 26)
Exclusion criteria
* Prolonged post-operative invasive ventilation * Invasive or non-invasive ventilation or oxygen therapy in the last month * ASA class IV or V * Emergency procedures * Pneumothorax or active pulmonary infection * Any contraindication to CPAP * Prolonged bed rest * Patient refusal to participate or to receive preventive CPAP
Design outcomes
Primary
| Measure | Time frame | Description |
|---|---|---|
| PaO2/FIO2 ratio | Two hours after the administration of CPAP | Increase of the PaO2/FIO2 ratio compared to the baseline value |
Secondary
| Measure | Time frame | Description |
|---|---|---|
| Esophageal pressure-time product (PTPes) | Two hours after the administration of CPAP | Increase of the PTPes compared to the baseline value |
Countries
Italy
Contacts
Primary ContactPaolo Pelosi, Prof.
Outcome results
None listed