Cognitive Impairment, Schizophrenia, Social Competence
Conditions
Brief summary
The overall objective of this project is to identify the neural signature of the impaired ability to relate socially seen in individuals with schizophrenia. A hypothesized path from the neural processes of social cognition, to social cognition assessed behaviorally, to real-life social interactions is examined. Secondary aims are to compare electrophysiological measures of high vs low level social cognition; to develop assessment methods of real-life behavior; and to increase the ecological validity of schizophrenia research. Much research within the field is devoid of personal meaning and interpersonal context. This project's use of personalized assessment allows for an ecologically valid approach to the social deficits of schizophrenia.
Interventions
This is not an intervention study
Sponsors
Oslo University Hospital
Study design
Observational model
CASE_CONTROL
Time perspective
CROSS_SECTIONAL
Eligibility
Sex/Gender
ALL
Age
17 Years to 55 Years
Healthy volunteers
Yes
Inclusion criteria
* schizophrenia * schizoaffective disorder
Exclusion criteria
* diabetes * Hyperthyroidism * severe head trauma * neurological disease
Design outcomes
Primary
| Measure | Time frame | Description |
|---|---|---|
| Neurophysiology: EEG | 1 day (when assessed) | EEG mu suppression paradigm using point-light displays |
| Neurophysiology: ERP | 1 day (when assessed) | ERP mentalizing paradigm (perspective taking) |
| Cognition | 1 day (when assessed) | Matrics Consensus Cognitive Battery |
| Negative symptoms: clinician-rated | 1 day (when assessed) | Positive and Negative Syndrome Scale (PANSS) 2. Objectively assessed using computerized software (FaceReader, PRAAT) of video-taped personal narratives produced by the participants |
| Negative symptoms: objective 1 | 1 day (when assessed) | FaceReader |
| Negative symptoms: objective 2 | 1 day (when assessed) | PRAAT |
| Social cognition: complex ToM | 1 day (when assessed) | Movie for the Assessment of Social Cognition |
| Social cognition: low level ToM | 1 day (when assessed) | The Hinting Task |
| Social cognition: facial emotion perception | 1 day (when assessed) | Pictures of Facial Affect |
| Social cognition: body language reading | 1 day (when assessed) | Emotion in Biological Motion test |
| Functioning | 1 day (when assessed) | Social Functioning Scale (SFS). Seven scales that can be combined into a total score. Mean score in a schizophrenia population = 100, SD = 15. For both the seven scales and the total score. |
| Real-world behaviour | 1 day (when assessed) | Day Reconstruction Method |
| Real-world social interactions | 1 day (when assessed) | Video-ethnography |
Outcome results
None listed