Study on Neurocognitive Plasticity in Patients With Focal and Drug-resistant Epilepsy

Feasibility Study on Neurocognitive Plasticity in Patients With Focal and Drug-resistant Epilepsy, Before and After Surgery. Evaluation by Functional and Anatomic Neuroimaging

Status

Completed

Phases

Study type

Interventional

Source

ClinicalTrials.gov

Registry ID

NCT03543267

Acronym

FaisPLASTICITE

Enrollment

Registered

2018-06-01

Start date

2017-10-21

Completion date

2022-07-05

Last updated

2025-06-13

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Epilepsy

Brief summary

This study consist of define anatomo-functional reorganization (plasticity) profiles for the mentioned cognitive functions, before surgery (chronic plasticity induced by the epileptogenic zone) in patients with drug-resistant epilepsy. For that, patients will have 2 MRI examinations, one before surgery and the second, between 3 and 8 months after surgery.

Interventions

OTHERMRI exam

MRI before and after resection surgery

Study design

Allocation

Intervention model

SINGLE_GROUP

Primary purpose

BASIC_SCIENCE

Masking

NONE

Eligibility

Sex/Gender

ALL

Age

18 Years to No maximum

Healthy volunteers

Inclusion criteria

* Patients with diagnosis of pharmaco-resistant focal epilepsy * Patient candidate for surgery to resect the epileptogenic zone * Patients affiliated to a social security scheme or beneficiaries of such a scheme * Patients with French as their mother tongue * Patients who have given signed informed consent before performing any procedure related to the study.

Exclusion criteria

* Contraindication to performing an MRI: * Intellectual disability objectified by a Mini Mental Score (MMS) score \<24 in the year preceding inclusion, * Existence of a severe condition in general: cardiac, respiratory, hematological, renal, hepatic, cancerous, * Participation in other research protocols underway with exclusion period or in the previous week, * Persons referred to in Articles L1121-5 to L1121-8 of the Public Health Code.

Design outcomes

Primary

Measure	Time frame	Description
to define anatomo-functional reorganization (plasticity) profiles by functional MRI for the mentioned cognitive functions, before surgery (chronic plasticity induced by the epileptogenic zone) in patients with drug-resistant epilepsy.	One hour and thirty minutes	The outcome measure is the hemispheric lateralization index (IL) before surgery measured by functional MRI

Countries

France

Outcome results

None listed

Source: ClinicalTrials.gov · Data processed: Feb 4, 2026