Placenta Previa
Conditions
Brief summary
Antepartum hemorrhage is defined as bleeding from or within the female genital tract, occurring from 28+0 weeks of pregnancy and till delivery of the fetus. it occurs in 3-5% of pregnancies and is an important cause of perinatal and maternal morbidity and mortality worldwide
Detailed description
There are many tocolytic agents may have a role in conservative management of placenta previa such as magnesium sulfate, calcium channel blockers and β-sympathormimetics. In 2004 Sharma suggests that ritodrine hydrochloride in patients with symptomatic placenta previa tends to prolong the pregnancy and result in an increase in birth weight of the babies without causing any adverse effect on the mother and fetus
Interventions
DRUGMagnesium Sulfate
Patients received intravenous 6 g bolus MgSO4 20% followed by a 2 g/h infusion
DRUGNifedipine
received oral nifedipine 10 mg every 20 minutes for three doses, followed by 10 mg orally every 6 hours
Sponsors
Assiut University
Study design
Allocation
RANDOMIZED
Intervention model
PARALLEL
Primary purpose
PREVENTION
Masking
NONE
Eligibility
Sex/Gender
FEMALE
Healthy volunteers
No
Inclusion criteria
* Estimated gestational age : between 28 weeks and 37 week's gestation * Confirmed Placenta previa; either major or minor degrees. * Placenta previa with preterm uterine contractions
Exclusion criteria
* Severe attack of bleeding requiring an immediate intervention. * Fetal heart rates instability or non-reassuring tracing * Intrauterine fetal death or major fetal anomalies. * If associated with abruptio placentae * Patients with known bleeding disorders or on anticoagulant therapy * Patients with severe medical disorders as myasthenia gravis documented magnesium toxicity.
Design outcomes
Primary
| Measure | Time frame | Description |
|---|---|---|
| The duration of prolongation of gestation | 1 month | measured from the time of enrollment to the time of delivery |
Countries
Egypt
Outcome results
None listed