Testosterone-Dependent Effects on Protein Biomarkers From Healthy Males

Testosterone-Dependent Effects on Protein Biomarkers From Healthy Males Before and After Pharmacological Castration

Status

Completed

Phases

Study type

Interventional

Source

ClinicalTrials.gov

Registry ID

NCT03541395

Enrollment

Registered

2018-05-30

Start date

2015-03-31

Completion date

2015-06-30

Last updated

2018-05-30

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Hypogonadism, Male

Brief summary

The study is designed to identify and validate new protein biomarkers in blood related to testosterone activity. Thirty healthy young males underwent pharmaceutical castration to lower testosterone levels. After three weeks the subjects received an intramuscular injection of testosterone undecanoate. Blood samples from just before pharmaceutical castration, three weeks after castration, and one week after injection of testosterone undecanoate were collected representing normal testosterone levels, low testosterone levels, and testosterone at eugonadal levels.

Interventions

DRUGGnRH antagonist

Study design

Allocation

Intervention model

SINGLE_GROUP

Primary purpose

BASIC_SCIENCE

Masking

NONE

Eligibility

Sex/Gender

MALE

Age

20 Years to 30 Years

Healthy volunteers

Yes

Inclusion criteria

healthy males

Exclusion criteria

use of anabolic steroids, use of narcotics,

Design outcomes

Primary

Measure	Time frame	Description
Protein biomarkers	48 months	Finding new protein biomarkers related to testosterone response

Outcome results

None listed

Source: ClinicalTrials.gov · Data processed: Feb 4, 2026