Inflammatory Bowel Diseases
Conditions
Keywords
muscle weakness, muscle mass, whole-body electromyostimulation, WB-EMS, nutrition, protein, crohn's disease, ulcerative colitis
Brief summary
Patients with inflammatory bowel disease (IBD) often suffer from muscle weakness and a low bone mineral density as a consequence of systemic Inflammation and disease treatment limiting Quality of life in a considerable way. Exercise interventions to build up muscle mass and increasing physical function are promising Tools to improve the whole muscular Status of those patients. However, in the acute Phase of IBDs conventional Training methods may be too strenous, also because patients are suffering from acute gastrointestinal symptoms and feel fatigued. Due to those symptoms, patients present low Food intake and great loss of nutrients and energy especially by diarrhea. Individualized nutritional Support may be helpful to avoid malnutrition. The aim of this pilot study is to investigate the effect of a combined exercise and Nutrition Intervention using the gentle Training method of whole-body electromyostimulation (WB-EMS) combined with a individual high Protein nutritional Support on muscle mass, Body composition, physical function, Quality of life and gastrointestinal symptoms in outpatients with IBD.
Interventions
OTHERWB-EMS
WB-EMS training is performed 2x/week for 12 weeks; Stimulation protocol: Frequency of 85 Hz, pulse duration of 0.35 ms, stimulation period of 6 sec, resting period of 4 sec; supervised by certified training instructors/physiotherapists participants perform simple exercises during the stimulation period following a video tutorial
OTHERNutritional support
dietary monitoring by dietary records; nutritional counselling by dietician, dietary advices: 1.5 g/kg bodyweight/day
Sponsors
University of Erlangen-Nürnberg Medical School
Study design
Allocation
RANDOMIZED
Intervention model
PARALLEL
Primary purpose
SUPPORTIVE_CARE
Masking
NONE
Eligibility
Sex/Gender
ALL
Age
18 Years to No maximum
Healthy volunteers
No
Inclusion criteria
* outpatients with inflammatory bowel disease (Crohn's disease, ulcerative Colitis) * adults (18 years and older)
Exclusion criteria
* simultaneous participation in other nutritional or exercise intervention Trials * acute cardiovascular events * use of anabolic medications * epilepsy * severe neurological diseases * skin lesions in the area of electrodes * energy active metals in body * pregnancy * acute vein thrombosis
Design outcomes
Primary
| Measure | Time frame | Description |
|---|---|---|
| Skeletal muscle mass | 12 weeks | assessed by bioelectrical impedance analysis in kg |
Secondary
| Measure | Time frame | Description |
|---|---|---|
| Physical activity | 12 weeks | IPAQ |
| Body composition | 12 weeks | assessed by bioelectrical impedance analysis in kg or % |
| Physical function - isometric muscle strength | 12 weeks | isometric hand grip strength assessed by hand dynamometer |
| Physical function - Endurance | 12 weeks | Six-minute-walk test (walking distance in m) |
| Quality of Life | 12 weeks | IBDQ-D |
| Disease activity (Crohn's disease) | 12 weeks | Harvey Bradshaw Index |
| Disease activity (ulcerative colitis) | 12 weeks | Mayo Score |
| Inflammation status | 12 weeks | C-reactive protein (CRP) |
| Physical function - lower limb strength | 12 weeks | isometric lower limb strength assessed by isometric force plates in N |
Countries
Germany
Outcome results
None listed