CB1R in Synthetic Psychoactive Cannabinoids

CB1R Availability in Synthetic Psychoactive Cannabinoid Users

Status

Active, not recruiting

Phases

Unknown

Study type

Interventional

Source

ClinicalTrials.gov

Registry ID

NCT03539575

Acronym

CB1R in Spice

Enrollment

Registered

2018-05-29

Start date

2018-05-01

Completion date

2026-12-01

Last updated

2026-04-29

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Drug Dependence

Keywords

K2, Spice, Synthetic Marijuana

Brief summary

The purpose of this research study is to determine whether the CB1R availability is lower in synthetic psychoactive cannabinoid subjects using the most widely available synthetic psychoactive cannabinoids at the time the study is initiated.

Interventions

OTHER[11-C]OMAR

The radiotracer, \[11-C\]OMAR will be administered at no more than 10 micrograms at the beginning of each PET scan.

Study design

Allocation

Intervention model

SINGLE_GROUP

Primary purpose

OTHER

Masking

NONE

Eligibility

Sex/Gender

ALL

Age

18 Years to 55 Years

Healthy volunteers

Yes

Inclusion criteria

Inclusion: * Able to provide written consent * Age 18-55 * Current Synthetic Psychoactive Cannabinoids consumption Exclusion: * MRI metal exclusions and claustrophobia * Education completed is less than 12 years

Design outcomes

Primary

Measure	Time frame	Description
Positron Emission Tomography (PET Imaging)	Change in CB1R availability from baseline throughout one test day	CB1R availability using \[11-C\]OMAR PET imaging Change in CB1R availability (e.g. volume distribution).

Secondary

Measure	Time frame	Description
CogState Battery	Change in CB1R availability from baseline throughout one test day	2\. Changes in Cognition during withdrawal using a computerized battery Changes in cognitive functions such as attention, memory, motor functioning, and processing speed.
Electroencephalogram	Change in CB1R availability from baseline throughout one test day	3\. Changes in brain rhythms measured by Electroencephalography Changes in electroencephalographic (EEG) brain rhythms related to information processing.

Countries

United States

Contacts

PRINCIPAL_INVESTIGATORDeepak C D'Souza, M.D.

Yale University

PRINCIPAL_INVESTIGATORMohini Ranganathan, M.D.