The Epigenetics of Exercise and Physical Activity in COPD

Status

UNKNOWN

Phases

Unknown

Study type

Observational

Source

ClinicalTrials.gov

Registry ID

NCT03539042

Enrollment

Registered

2018-05-29

Start date

2018-03-01

Completion date

2021-06-30

Last updated

2018-05-30

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Copd

Keywords

DNA methylation, Physical activity, Exercise capacity

Brief summary

This study seeks to examine genome-wide DNA methylation patterns associated with physical activity and exercise capacity from peripheral blood collected from participants with chronic obstructive pulmonary disease (COPD) before and after participation in a structured 9-week outpatient pulmonary rehabilitation program.

Detailed description

Individuals who are referred to pulmonary rehabilitation IN THE COURSE OF THEIR USUAL CLINICAL CARE will be invited to participate in this observational study. Participants who enroll in the study will undergo two in-person visits, once before initiating pulmonary rehabilitation classes and once at the conclusion of pulmonary rehabilitation classes. Participation in this study will not alter the course of the participants' usual clinical care.

Interventions

None listed

Study design

Observational model

COHORT

Time perspective

PROSPECTIVE

Eligibility

Sex/Gender

ALL

Age

40 Years to No maximum

Healthy volunteers

Inclusion criteria

* Age \>40 years * Diagnosis of COPD (defined as an FEV1/FVC\<0.7 or evidence of emphysema on radiologist's read of a chest CT obtained in the course of patient's usual care) * Referral to and participation in the VA Boston Pulmonary Rehabilitation program

Exclusion criteria

* Active or unstable cardiac disease * Inability to ambulate \> 1 block * Recent acute exacerbation of COPD (defined as new or increased dose of systemic steroids and/or antibiotics for pulmonary indications)

Design outcomes

Primary

Measure	Time frame	Description
Change in DNA methylation patterns	Baseline and 3-month follow up	Baseline patterns and changes over time after participation in exercise training

Secondary

Measure	Time frame	Description
Change in 6MWD	Baseline and 3-month follow up	Change in exercise capacity (assessed as 6 minute walk distance) after exercise training in pulmonary rehabilitation
Change in average daily step count	Baseline and 3-month follow up	Change in pedometer assessed daily step count before and after exercise training in pulmonary rehabilitation

Countries

United States

Outcome results