Fetal Distress
Conditions
Keywords
copeptin levels, Cesarean section, general anesthesia, spinal anesthesia
Brief summary
In this study, investigators aimed to investigate the effects of general and spinal anesthesia techniques on copeptin levels during cesarean section and their relation with fetal distress.
Detailed description
During the delivery process, the mother and the baby generate some endocrine responses to this emotional and physical stressful action. Arginin-Vasopressin prohormone (copeptin), which is more stable and measurable in blood, is used as an endogenous stress indicator. Copeptin levels have been shown to be significantly increased in vaginally delivery when compared to cesarean section (c / s). In a caesarean section; it is a known fact that when the general anesthetic method and the used anesthetic substances are taken into consideration, it gives a significant stress to the mother and the baby. Spinal anesthesia with no impaired fetal oxygenation and without orotracheal intubation and neuromuscular blockers may reduce fetal distress. However, there was no study investigating the effect of the anesthesia techniques in elective cesarean section on the fetal stress and the level of copeptin, in the literature review. Therefore investigators aimed to compare spinal and general anesthesia technique in elective cesarean section, to evaluate level of copeptin and their relation with fetal distress.Investigators hope that this study will guide the anesthesia method that can be chosen primarily in caesarean section.
Interventions
OTHERCopeptin
Level of copeptin in maternal blood and umbilical cord blood
Sponsors
Istanbul University
Study design
Allocation
RANDOMIZED
Intervention model
PARALLEL
Primary purpose
OTHER
Masking
QUADRUPLE (Subject, Caregiver, Investigator, Outcomes Assessor)
Eligibility
Sex/Gender
FEMALE
Age
18 Years to 40 Years
Healthy volunteers
Yes
Inclusion criteria
* 18-40 years of age * ASA I-II * 36-40 gestational weeks * BMI ≤ 40 * Undergoing elective cesarean section
Exclusion criteria
* Coagulopathy * Known central or peripheral nerve disease * fetal anomalies * birth weight less than 2000 grams and above 4500 grams, * infants with a risk of meconium or amniotic fluid aspiration * kidney failure, diabetes mellitus, hypertension, cardiac disease, antepartum hemorrhage, asthma bronchiole, Rh incompatibility, congenital malformations
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| Changes in copeptin levels after general or spinal anesthesia | Baseline and immediately after surgery from maternal blood and arterial and venous umbilical cord at birth |
Countries
Turkey (Türkiye)
Outcome results
None listed