Impact of Renal Replacement Therapy on Coagulation Profile of Patients with Acute Renal Failure

Impact of Renal Replacement Therapy on Coagulation Profile in Patients with Acute Renal Failure

Status

Completed

Phases

Unknown

Study type

Observational

Source

ClinicalTrials.gov

Registry ID

NCT03536195

Acronym

HEMOSTIR

Enrollment

Registered

2018-05-24

Start date

2018-08-18

Completion date

2021-11-23

Last updated

2025-03-24

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Acute Renal Failure, Coagulation Disorder, Hemorrhage

Keywords

renal replacement therapy, acute renal failure, coagulation, bleeding

Brief summary

Renal failure and high plasmatic level of urea have been associated with an increased risk of hemorrhage in surgical patients. There is only sparse data on the impact of renal replacement therapy on homeostatic parameters. The aim of this study is to describe potential changes in homeostatic parameters before and after renal replacement therapy.

Interventions

None listed

Study design

Observational model

COHORT

Time perspective

PROSPECTIVE

Eligibility

Sex/Gender

ALL

Age

18 Years to No maximum

Healthy volunteers

Inclusion criteria

* critically ill patients * acute renal failure * renal replacement therapy * plasmatic urea \> 20

Exclusion criteria

* chronic renal failure * platelet count less than 80 Giga * V factor less than 70%

Design outcomes

Primary

Measure	Time frame	Description
visco elastometry	Change in ROTEM parameters from baseline to after renal replacement therapy	ROTEM (Rotational Thromboelastometry)

Countries

France

Outcome results