Bilirubin Encephalopathy, Cerebral Infarction, Hypoglycemia, Neonatal, Hypoxic-Ischemic Encephalopathy, Intraventricular Hemorrhage Neonatal, Kernicterus, Periventricular Leukomalacia
Conditions
Keywords
treadmill, infants, neonatal encephalopathy, neonatal brain injury
Brief summary
There have been many studies on the use of running training in older children to improve gait development in children with cerebral palsy. The aim of our study was to conduct early treadmill training in infants who were highly suspected of cerebral palsy and to follow up on their long-term gait development.
Interventions
DEVICEBaby treadmill
The newborns who received treadmill intervention were stimulated by running 3 times a week for a total of 10 minutes each time (complete in 5 cycles, 2 minutes per cycle, 2 minutes after the completion of one cycle and rest for 2 minutes to start the next cycle). Until the completion and completion of the five cycles). During the remaining four days of each week, other physical rehabilitation training is carried out by the rehabilitator in accordance with the established rehabilitation plan. The stimulation of running lasted from 3 months of corrected gestational age to being able to walk alone for 3 steps or to correct for 18 months.
BEHAVIORALConventional physical rehabilitation training
Suitable for general physical rehabilitation training of all infants with cerebral palsy.
Sponsors
Shanghai High-risk Infants Early Intervention Center
Children's Hospital of Fudan University
Study design
Allocation
NON_RANDOMIZED
Intervention model
PARALLEL
Primary purpose
PREVENTION
Masking
NONE
Intervention model description
Parallel Assignment All subjects were divided into two groups: intervention group A (treadmill intervention + routine physical rehabilitation therapy) and positive control group (receiving routine physical rehabilitation therapy only).
Eligibility
Sex/Gender
ALL
Age
No minimum to 3 Months
Healthy volunteers
No
Inclusion criteria
1. Gestational age \< 33W; 2. Correction of gestational age \< 3 months; 3. It has been diagnosed as hypoxic-ischemic encephalopathy, periventricular intraventricular hemorrhage, periventricular leukomalacia, bilirubin encephalopathy, persistent hypoglycemia and cerebral infarction. 4. There was no other therapeutic intervention before entering the study; 5. Informed consent is signed by the family.
Exclusion criteria
1. Brain injury caused by central or peripheral infection (cerebrospinal fluid positive / torch test positive / three major conventional culture positive); 2. Brain damage caused by convulsion; 3. Metabolic brain damage caused by genetic defects; 4. Suffering from known severe congenital malformations; 5. Definite head trauma during labor or postpartum; 6. Peripheral neuromuscular disease or abnormal skeletal system.
Design outcomes
Primary
| Measure | Time frame | Description |
|---|---|---|
| step frequency | The length of time from birth to the corrected age of 18 months | This variable is a number that records the infants' number of coordinated gaits in all gait training processes. |
| age of onset of independent walking | The length of time from birth to the corrected age of 2 years | This variable is a gait parameter, recording a point in time the baby will start walking independently. |
Secondary
| Measure | Time frame | Description |
|---|---|---|
| step width | The length of time from birth to the corrected age of 18 months | The vertical distance between the parallel lines of two medial plantar edges |
| gait double-limb support | The length of time from birth to the corrected age of 18 months | The percentage of two-limb support gait in the whole training process. |
| age of onset of walking with assistance | The length of time from birth to the corrected age of 2 years | This variable is a gait parameter, recording a point in time the baby will start walking with assistance. |
| toe-off | The length of time from birth to the corrected age of 18 months | The percentage of toe-off gait in the whole training process. |
| gait ankle dorsiflexion | The length of time from birth to the corrected age of 18 months | The percentage of ankle dorsiflexion gait in the whole training process. |
| gait ankle plantar flexion | The length of time from birth to the corrected age of 18 months | The percentage of gait ankle plantar flexion in the whole training process. |
| step length | The length of time from birth to the corrected age of 18 months | The length of displacement formed by the same foot after completing a gait. |
Countries
China
Outcome results
None listed