Infertility, Female, Myoma;Uterus
Conditions
Brief summary
The investigators analyzed a group of infertile women treated with Ulipristal Acetate (UA) for uterine fibroids at the Humanitas Fertility Center. All the patients' data were extracted from the Fertility Center external-audit-anonymized electronic research query system.
Detailed description
In the recent years several large studies have been published on the efficacy of Ulipristal Acetate treatment of moderate to severe symptoms of uterine fibroids in adult women: initially proposed only as pre-surgical treatment, the UA was subsequently also used for the long-term treatment of uterine myomas symptoms. However, few data are available on the effects of UA in terms of increasing fecundability, implantation and pregnancy outcome and safety in the general population, and in infertile patients in particular. This retrospective study aims at describing the correlation between the use of Ulipristal Acetate and pregnancy outcome in infertile patients and at comparing the UA plus surgery approach to the UA-only treatment in terms of pregnancy outcome.
Interventions
None listed
Sponsors
Istituto Clinico Humanitas
Study design
Observational model
COHORT
Time perspective
RETROSPECTIVE
Eligibility
Sex/Gender
FEMALE
Age
18 Years to 45 Years
Healthy volunteers
No
Inclusion criteria
* infertile women received at least 1 month of therapy with UA 5 mg/day for uterine fibroids * more of 1 year of active pregnancy seeking Exclusion: * menopausal women;
Design outcomes
Primary
| Measure | Time frame | Description |
|---|---|---|
| implantation rate | 2013 - 2018 | number of intrauterine gestational sacs observed divided by the number of transferred embryos |
Secondary
| Measure | Time frame | Description |
|---|---|---|
| myomas reduction | 2013 - 2018 | volumetric reduction in after therapy |
Countries
Italy
Outcome results
None listed