Difficult Embryo Transfer
Conditions
Brief summary
IVF/ICSI patients who had difficult mock embryo transfer on the day of ovum pick up. Will be randomly assigned into two groups; group A will receive 100mg indomethacin rectal suppository 1-2 hours before ET and group B will not receive indomethacin
Interventions
DRUGIndomethacin 100Mg Suppository
Indomethacin 100Mg Suppository will be given 1 to 2 hours before embryo transfer in cases with difficult mock embryo transfer in the active comparator group.
PROCEDUREIVF/ICSI
patients received induction with the long agonist stimulation protocol. Followed by ovum pickup and embryo transfer. Only those with difficult mock embryo transfer will be recruited in this study.
Sponsors
Nile Ivf Center, Cairo, Egypt
Cairo University
Study design
Allocation
RANDOMIZED
Intervention model
PARALLEL
Primary purpose
PREVENTION
Masking
NONE
Eligibility
Sex/Gender
FEMALE
Age
20 Years to 38 Years
Healthy volunteers
Yes
Inclusion criteria
* Infertile patients undergoing IVF cycle with difficult mock embryo transfer * Early follicular FSH level ≤10 IU/L. * Tubal, male infertility and unexplained causes of fertility will be recruited. * Fresh ET.
Exclusion criteria
* Repeated IVF failure. * Past history of allergy to NSAID, bronchial asthma , peptic ulcer or inflammatory bowel disease. * Easy mock embryo transfer.
Design outcomes
Primary
| Measure | Time frame | Description |
|---|---|---|
| Implantation rate | 6 weeks | the number of total gestational sacs divided by the total number of embryos transferred. |
Secondary
| Measure | Time frame | Description |
|---|---|---|
| Clinical pregnancy rate | 6 weeks | Presence of fetal pulsations after 2 weeks from the positive pregnancy test. |
| Ongoing pregnancy rate | 12 weeks | Pregnancies continuing beyond 12 weeks |
Countries
Egypt
Outcome results
None listed