Lung Compliance
Conditions
Brief summary
The investigators assess the changes in respiratory compliance according to different levels of positive end expiratory pressure (PEEP) in children under general anesthesia. In addition, the investigators evaluate the intratidal compliance-volume profile at each PEEP level and determine the optimal PEEP level during anesthesia.
Interventions
The different levels of PEEP, 5 cmH2O, 8 cmH2O and 12 cmH2O, are applied serially. Mean respiratory compliance and intratidal compliance-volume profile are evaluated.
Sponsors
Seoul National University Hospital
Study design
Allocation
NA
Intervention model
SINGLE_GROUP
Primary purpose
DIAGNOSTIC
Masking
NONE
Eligibility
Sex/Gender
ALL
Age
No minimum to 6 Years
Healthy volunteers
No
Inclusion criteria
* Children undergoing surgery more than 1 hour under general anesthesia * American Society Anesthesiologist physical status I, II
Exclusion criteria
* History of lung resection * History of bronchopulmonary dysplasia or respiratory distress syndrome * Abnormalities in chest radiography * Laparoscopic surgery * Abdominal surgery
Design outcomes
Primary
| Measure | Time frame | Description |
|---|---|---|
| Mean respiratory compliance | During 15 minutes after applying each level of PEEP | Mean static and dynamic compliance |
Secondary
| Measure | Time frame | Description |
|---|---|---|
| Compliance profile | During 15 minutes after applying each level of PEEP | We will determine Intratidal compliance-volume profile using the changes in compliance over time --\> I, merely increasing compliance profile; IH, increasing turning into horizontal compliance profile; D, merely decreasing compliance profile; HD, horizontal turning into decreasing compliance profile; IHD, increasing turning into horizontal and further turning into decreasing compliance profile If compliance profile is I, the PEEP is low. On the other hand, compliance profile is D, PEEP level is considered to be high. |
| Airway resistance | During 15 minutes after applying each level of PEEP | Mean airway resistance |
Countries
South Korea
Outcome results
None listed