Comparing Brain Images Before and After MRI-upgrade - TimFit Upgrade Study

Brain Images Before and After Upgrade of the MRI-scanner (Siemens Tim TRIO vs Siemens PRISMA FIT) - The TimFit Study

Status

Completed

Phases

Study type

Interventional

Source

ClinicalTrials.gov

Registry ID

NCT03531580

Enrollment

Registered

2018-05-21

Start date

2017-11-29

Completion date

2018-06-30

Last updated

2021-12-01

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Neuroimaging, Quality Control

Brief summary

In the Ghent University, an upgrade of the MRI-scanner used for research from Siemens Trio Tim to Siemens Prisma Fit is planned in the near future. As a change of MRI hard- and software might influence brain images, it is necessary to evaluate the images before and after the upgrade.

Interventions

DEVICEMagnetic Resonance Imaging

Brain imaging using magnetic resonance imaging, using several MRI sequences: structural imaging (grey matter, using T1-imaging), cerebral perfusion using arterial spin labeling), functional and effective connectivity (using resting-state functional MRI), white matter tracts (using diffusion imaging), white matter lesions (using Fluid-attenuated inversion recovery MRI (FLAIR)) and microbleeds (using Susceptibility weighted imaging (SWI))

Study design

Allocation

Intervention model

SINGLE_GROUP

Primary purpose

OTHER

Masking

NONE

Eligibility

Sex/Gender

ALL

Age

20 Years to No maximum

Healthy volunteers

Yes

Inclusion criteria

* Healthy volunteer

Exclusion criteria

* Protheses or artificial implants, no magnetic or metal parts in the body * Being pregnant or breastfeeding * Having claustrophobia

Design outcomes

Primary

Measure	Time frame
Change in grey matter volume before versus after MRI-upgrade	7 months, 4 scan sessions of max 1 hour
Change in cerebral perfusion (ml/100g/min) using Arterial Spin Labeling before versus after MRI-upgrade	7 months, 4 scan sessions of max 1 hour
Change in arterial transit times before versus after MRI-upgrade	7 months, 4 scan sessions of max 1 hour
Change in functional connectivity (fc) using Resting State functional MRI before versus after MRI-upgrade	7 months, 4 scan sessions of max 1 hour
Change in effective connectivity using resting state functional MRI before versus after MRI-upgrade	7 months, 4 scan sessions of max 1 hour
Change in white matter diffusion before versus after MRI-upgrade	7 months, 4 scan sessions of max 1 hour
Difference in image quality of FLAIR image before versus after MRI-upgrade	7 months, 4 scan sessions of max 1 hour
Difference in image quality of SWI image before versus after MRI-upgrade	7 months, 4 scan sessions of max 1 hour

Countries

Belgium

Outcome results

None listed

Source: ClinicalTrials.gov · Data processed: Feb 4, 2026