Lactate Levels Correlates With Ki-67 in Brain Tumor Surgery

Lactate Levels at Beginning of Surgery Correlates With Ki-67 Labeling Index in Brain Tumors

Status

Completed

Phases

Unknown

Study type

Observational

Source

ClinicalTrials.gov

Registry ID

NCT03531307

Enrollment

100

Registered

2018-05-21

Start date

2018-05-30

Completion date

2018-08-02

Last updated

2019-02-15

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Anesthesia, Brain Tumor

Keywords

Lactate, Ki-67, Mitotic index, Brain tumor

Brief summary

In neurosurgery, brain tumor patients show increased levels of lactate at the beginning of surgery. This has been related to malignancy. Ki-67 is a cell proliferation index used as a marker of tumor mitotic activity. This research aims to describe the correlation between lactate levels and the Ki-67 index in patients with brain tumor.

Detailed description

Lactate levels are used in the evaluation of perfusion status in critical care. Increases not related to a hypoperfusion state are observed in the patient with brain tumors. These increases have been related to type and tumor grade. This observation does not fully explain the variation within the same tumor grade. Ki-67 label index is a marker of mitotic activity that can be used as proliferation index. It has been associated with histologic grade and survival rate. Provides a quantitative measure of the tumor proliferation status. The investigators will perform a retrospective analysis of the clinical charts of patients after brain tumor resection. The study will address the relationship between baseline lactate levels and the proliferation index found in tissues biopsies.

Interventions

OTHERData correlation

Correlation between lactate levels and Ki-67 index

Study design

Observational model

CASE_ONLY

Time perspective

RETROSPECTIVE

Eligibility

Sex/Gender

ALL

Healthy volunteers

Inclusion criteria

* Neurosurgical craniectomy cases * June 2017 - February 2018 * Valid lactate information after anesthesia induction * Ki-67 label index informed in biopsies * Tumor type information confirmed in biopsies

Exclusion criteria

* Incomplete lactate or Ki-67 index information

Design outcomes

Primary

Measure	Time frame	Description
Evaluate the correlation between Lactate levels and Ki-67 Index	Within 1 week after data acquisition	Levels of lactate in first blood analysis after anesthesia induction and proliferation index in biopsy results

Countries

Spain

Outcome results

None listed

Source: ClinicalTrials.gov · Data processed: Feb 4, 2026