Shivering, Ondansetron
Conditions
Brief summary
Shivering is one of the most frequent complications occurring during or after spinal anesthesia with many side effects. The aim of the present study was to compare between two different doses of ondansetron for anti-shivering effect
Detailed description
Shivering is one of the most frequent complications occurring during or after spinal anesthesia, it affects about 40%-60 % of patients under spinal anesthesia. Intra and Post spinal shivering is distressing for the patients and anesthetist. Shivering may aggravate medical conditions in patients with limited cardiac or respiratory functions. It increases tissue oxygen demand many folds which in turn leads to increase the load on respiratory and cardiac systems to cope with increased aerobic metabolism. Shivering interferes with good patient monitoring by causing artifacts of electrocardiography, invasive and non-invasive blood pressure, pulse oximetry, etc... . Postoperatively shivering may cause discomfort to the patient, increases wound pain by stretching incision, increase the incidence of bleeding and infection. We aim to compare the prophylactic use of two different doses of ondansetron on the incidence of shivering after spinal anesthesia in patients scheduled for lower limb surgery. The primary outcome was percentage of patients suffering from shivering after spinal anesthesia, secondary outcomes include any side effects related to both doses.
Interventions
DRUGNormal saline
normal saline used for prevention of spinal shivering
DRUGOndansetron 4 MG
ondansetron 4 MG used for prevention of spinal shivering
DRUGOndansetron 8mg
ondansetron 8 MG used for prevention of spinal shivering
Sponsors
Assiut University
Study design
Allocation
RANDOMIZED
Intervention model
PARALLEL
Primary purpose
PREVENTION
Masking
TRIPLE (Subject, Caregiver, Outcomes Assessor)
Eligibility
Sex/Gender
ALL
Age
18 Years to 60 Years
Healthy volunteers
No
Inclusion criteria
* Age between 18-65 years * Both sexes * American Society of Anesthesiologists * physical status I and II * scheduled for lower limb surgery under spinal anesthesia
Exclusion criteria
* Uncooperative patients * psychologically unstable patients * obese patients with BMI \>30 preoperative use of ondansetron, or opioids Fever Patients with some clinical conditions like hypo- or hyperthyroidism, Parkinson's disease.
Design outcomes
Primary
| Measure | Time frame | Description |
|---|---|---|
| incidence of shivering | for 24 hours after spinal anesthesia | Incidence of shivering among patients in both groups |
Secondary
| Measure | Time frame | Description |
|---|---|---|
| incidence of hypotension | for 24 hours after spinal anesthesia | Incidence of hypotension between patients in both groups |
| incidence of nausea and vomiting | for 24 hours after spinal anesthesia | Incidence of nausea and vomiting among patients in both groups |
| Axillary temperature | for 24 hours after spinal anesthesia | patient temperature measured from axillary site |
| core temperature | for 24 hours after spinal anesthesia | patient temperature measured from tympanic site |
Outcome results
None listed