Work of Breathing and Oxygen Saturation in Infants Receiving High Flow Nasal Cannula (HFNC)

Work of Breathing and Oxygen Saturation Stability in Infants With Respiratory Insufficiency While Receiving Various Flow Rates of High Flow Nasal Cannula

Status

Completed

Phases

Unknown

Study type

Observational

Source

ClinicalTrials.gov

Registry ID

NCT03529994

Enrollment

Registered

2018-05-21

Start date

2018-04-15

Completion date

2019-08-01

Last updated

2019-08-28

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

High Flow Nasal Cannula

Brief summary

The purpose of this study is to compare work of breathing on different levels of high flow respiratory support on infants born between 27 and 37 weeks gestation.

Interventions

OTHEREnrollment

All infants enrolled will have work of breathing assessed.

Study design

Observational model

COHORT

Time perspective

PROSPECTIVE

Eligibility

Sex/Gender

ALL

Age

No minimum to 6 Months

Healthy volunteers

Yes

Inclusion criteria

* Infants between 27 and 37 weeks corrected gestational age * \>4 days PNA * Stable (i.e. not meeting

Exclusion criteria

) and receiving non-invasive respiratory support (HFNC) for ≥ 12 hours * Requiring ≤ 40% supplemental FiO2 as determined by the clinical care team for clinical care purposes independent of this study

Design outcomes

Primary

Measure	Time frame	Description
Work of breathing indices	2 hours	Altering HFNC flow rates and its effect on work of breathing indices in preterm infants with respiratory insufficiency.

Secondary

Measure	Time frame	Description
Intermittent hypoxia	2 hours	Altering HFNC flow rates and its effect on intermittent hypoxia in preterm infants with respiratory insufficiency.

Countries

United States

Outcome results

None listed

Source: ClinicalTrials.gov · Data processed: Feb 4, 2026