The Early Rehabilitation Program in Post-LT Pts

The Safety and Efficacy of Early Rehabilitation Program in Immediate Liver Transplant Patients

Status

Completed

Phases

Study type

Interventional

Source

ClinicalTrials.gov

Registry ID

NCT03529656

Enrollment

236

Registered

2018-05-18

Start date

2014-10-01

Completion date

2017-03-31

Last updated

2018-05-18

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

ICU-acquired Weakness

Keywords

Liver transplantation, rehabilitation, ICU acquired weakness

Brief summary

The purpose of this study is to determine whether an early rehabilitation program for immediate liver transplant patients is safe and effective in preventing critical care illness and intensive care unit acquired weakness.

Detailed description

Patients with liver transplantation (LT) have poor general condition before surgery and require ICU care for a certain period. For those patients, the side effects of ICU care such as intensive care unit-acquired weakness (ICU-AW), critical illness polyneuropathy (CIP) are well known. Therefore, we access the safety and efficacy of early rehabilitation program (ERP) in liver transplant recipients. Patients were retrospectively selected for the Pre-ERP group (2014.05-2014.10) and for the Post-ERP group (2015.10-2016.03). During the period of 6 months, 136 patients and 100 patients underwent LT, and 65, 62 patients were enrolled after exclusion. Forty patients from the each group were compared after propensity score matching (PSM).

Interventions

BEHAVIORALEarly rehabilitation program for liver transplantation

Deliver the one of 5-step early rehabilitation program for immediate liver transplant pts on weekday

Study design

Allocation

NON_RANDOMIZED

Intervention model

PARALLEL

Primary purpose

SUPPORTIVE_CARE

Masking

NONE

Eligibility

Sex/Gender

ALL

Age

18 Years to No maximum

Healthy volunteers

Inclusion criteria

* immediate post liver transplant patients

Exclusion criteria

* patients who transferred to sub-ICU within 72 hours re-liver transplantation case wound, mental problem post op bleeding unstable vital

Design outcomes

Primary

Measure	Time frame
ICU day (days)	up to 60 days
ventilator day (days)	up to 60 days

Secondary

Measure	Time frame
Time to start rehabilitation from ICU admission (days)	up to 2 weeks
in-hospital LOS (days)	up to 24 weeks
hospital readmission rate after surgery (%)	1 year follow up from the surgery
1 year mortality rate (%)	1 year follow up from the surgery

Outcome results

None listed

Source: ClinicalTrials.gov · Data processed: Feb 4, 2026