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Effect of Anesthetic Method on Optic Nerve Sheath Diameter in Patients Undergoing RALP

Effect of Anesthetic Method on Optic Nerve Sheath Diameter in Patients Undergoing Robot-assisted Laparoscopic Prostatectomy: Comparison of Sevoflurane-remifentanil and Sevoflurane-remifentanil-dexmedetomidine

Status
Completed
Phases
NA
Study type
Interventional
Source
ClinicalTrials.gov
Registry ID
NCT03529643
Enrollment
128
Registered
2018-05-18
Start date
2018-05-24
Completion date
2018-08-22
Last updated
2018-09-13

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Prostate Cancer

Brief summary

The purpose of this study was to evaluate the effect of anesthetic method on the optic nerve sheath diameter in patients undergoing robot-assisted laparoscopic prostatectomy.

Detailed description

The purpose of this study was to evaluate the difference between the optic nerve sheath diameter measured during anesthesia with sevoflurane-remifentanil-dexmedetomidine and the optic nerve sheath diameter measured during anesthesia with sevoflurane-remifentanil in patients undergoing robot-assisted laparoscopic prostatectomy.

Interventions

DRUGDexmedetomidine

Anesthesia with sevoflurane-remifentanil-dexmedetomidine

OTHERWithout dexmedetomidine

Anesthesia with sevoflurane-remifentanil

Sponsors

Asan Medical Center
Lead SponsorOTHER

Study design

Allocation
RANDOMIZED
Intervention model
PARALLEL
Primary purpose
OTHER
Masking
QUADRUPLE (Subject, Caregiver, Investigator, Outcomes Assessor)

Eligibility

Sex/Gender
MALE
Age
20 Years to 79 Years
Healthy volunteers
No

Inclusion criteria

* Undergone a robot-assisted laparoscopic prostatectomy with a prostate - cancer * 20 years of age or older and under 80 years of age * Agree to participate in this study

Exclusion criteria

* History of cerebral hemorrhage or cerebral infarction * \< 20 years of age * ≥ 80 years of age * Glaucoma * Unexpected hemodynamic instability during surgery * Failure to measure optic nerve sheath diameter * Convert to open surgery

Design outcomes

Primary

MeasureTime frameDescription
Difference in optic nerve sheath diameter60 minutes after pneumoperitoneum and steep Trendelenburg positionDifference between the optic nerve sheath diameter measured during anesthesia with sevoflurane-remifentanil-dexmedetomidine and the optic nerve sheath diameter measured during anesthesia with sevoflurane-remifentanil in patients undergoing robot-assisted laparoscopic prostatectomy

Secondary

MeasureTime frameDescription
Difference in optic nerve sheath diameter30 minutes after pneumoperitoneum and steep Trendelenburg positionDifference between the optic nerve sheath diameter measured during anesthesia with sevoflurane-remifentanil-dexmedetomidine and the optic nerve sheath diameter measured during anesthesia with sevoflurane-remifentanil in patients undergoing robot-assisted laparoscopic prostatectomy.

Countries

South Korea

Outcome results

None listed

Source: ClinicalTrials.gov · Data processed: Feb 4, 2026