Inflammatory Bowel Diseases, Irritable Bowel Syndrome
Conditions
Brief summary
Crohn's disease and ulcerative colitis are types of chronic intestinal disorder called inflammatory bowel diseases (IBD) that can affect the small and large bowel causing symptoms of abdominal pain, diarrhea, blood in the stool, and weight loss. Irritable bowel syndrome (IBS) is a milder form of IBD, with symptoms of abdominal pain, bloating, diarrhea or constipation, and blood in the stool. It is not known what causes diseases such as IBD and IBS. This study will look at the events in the gut that leads to leaky gut and inflammation in patients with IBD and IBS. The study will also see if medications such as rifaximin and mesalamine may reduce the amount of leaky gut.
Interventions
PROCEDUREBiopsies from endoscopy
1\) Patients scheduled for endoscopy (EGD or colonoscopy) for IBD will be consented to allow physicians who are performing endoscopies to take additional biopsies and blood samples for research purposes.
Sponsors
University of Arkansas
Study design
Observational model
CASE_ONLY
Time perspective
PROSPECTIVE
Eligibility
Sex/Gender
ALL
Age
18 Years to 99 Years
Healthy volunteers
No
Inclusion criteria
* Men and women, 18-years old and older * Presenting at the University of Arkansas for Medical Sciences (UAMS) Endoscopy center to undergo endoscopy with biopsy for surveillance, screening or diagnosis.
Exclusion criteria
* Subjects classified in an anesthesia risk group , American Society of Anesthesiologists Class (ASA) ≥ 4, * history of bleeding diathesis or coagulopathy * stroke or transient neurological attack within the last 6 months * pregnancy * currently on blood thinners (excepting aspirin) * subject is unable to consent themselves
Design outcomes
Primary
| Measure | Time frame | Description |
|---|---|---|
| The number of specimens showing elevated levels of mucosal innate immune activation | Up to 2 years | Determining the level of mucosal innate immune activation by staining, organoid culture, Western blot analysis, and cytokine expression on biopsy samples in IBD and IBS patient samples. |
Countries
United States
Outcome results
None listed