Pain, Postoperative, Chronic Postoperative Pain
Conditions
Brief summary
Oxycodone consumption and postoperative pain intensity in patients undergoing nephrectomy procedures. Of all study participants, 50% will obtain quadratus lumborum block (QLB).
Detailed description
Patients undergoing nephrectomy procedures will be allocated to one of the study arms. At the end of an operation, still under general anesthesia, 50% patients will obtain QLB with ropivacaine. Ultrasound-guided QLB will be performed on the side of surgery with 0.375% ropivacaine solution (0.2 mL per kg). Every patient will get patient-controlled analgesia pump with oxycodone in the postoperative period. Postoperative pain will be measured with VAS (visual-analogue scale) 2, 4, 8, 12 and 24 hours after the end of the operation. 24 -hours period. At the 1, 3, 6 months patients will be interviewed by phone to assess neuropathic pain. Neuropathic Pain Symptom Inventory (NPSI) will be used.
Interventions
Sponsors
Department of Anesthesiology and Intensive Care, F. Chopin Hospital in Rzeszów
Department of Anesthesiology and Intensive Care, J. Śniadecki Hospital in Białystok
Medical University of Lublin
Study design
Allocation
RANDOMIZED
Intervention model
PARALLEL
Primary purpose
TREATMENT
Masking
SINGLE (Subject)
Masking description
A regional block will be performed under general anesthesia. Patients will not be aware of this procedure.
Intervention model description
Patients will be randomly allocated to one of the study arms: QLB or control group.
Eligibility
Sex/Gender
ALL
Age
18 Years to 80 Years
Healthy volunteers
No
Inclusion criteria
* obtained consent * nephrectomy procedure
Exclusion criteria
* coagulopathy allergy to local anesthetics depression, antidepressant drugs treatment epilepsy usage of painkiller before surgery addiction to alcohol or recreational drugs
Design outcomes
Primary
| Measure | Time frame | Description |
|---|---|---|
| Total consumption of oxycodone | 24 hours after the end of surgery. | Overall use of oxycodone administered by PCA pump will be assessed. |
Secondary
| Measure | Time frame | Description |
|---|---|---|
| Pain intensity | 24 hours after the end of surgery | Pain intensity measured on VAS scale at the 2, 4, 8, 12, 24 hours. VAS in milimmeters. Minimum value 0, maximum 100. Less better - less severe pain. 0 no pain at all. |
| Chronic pain | 6 months after the surgery | Chronic pain occurrence assessed with Neuropathic Pain Symptom Inventory (NPSI) 10 descriptive variables, each one from 0 to 10. 0 means no pain. 10 very high chance of occurrence of neuropathic pain. |
Countries
Poland
Outcome results
None listed