Hemodialysis Complication
Conditions
Brief summary
Uremic toxins such as p-cresol and phenol are suggested to be associated with higher mortality in hemodialysis patients. The aim of this study was to investigate the effects of probiotics on serum p-cresol level in hemodialysis patients.
Detailed description
Overall, 42 hemodialysis patients (10 women and 32 men) were divided randomly into the Lactobacillus rhamnosus group (21 patients) and the placebo group (21 patients).
Interventions
DIETARY_SUPPLEMENTLactobacillus rhamnosus
daily one capsule containing 1.6\*107 CFU of Lactobacillus Rhamnosus prepared by Tabriz Nutrition Research Center from yogurt and cheese of different farms located in the suburbs Heris, after meal for 28 days
DRUGPlacebo - Cap
daily one capsule of placebo
Sponsors
nooshin dalili
Study design
Allocation
RANDOMIZED
Intervention model
PARALLEL
Primary purpose
TREATMENT
Masking
DOUBLE (Subject, Investigator)
Eligibility
Sex/Gender
ALL
Age
20 Years to No maximum
Healthy volunteers
No
Inclusion criteria
• Age more than 20 years * Acceptable performance of alimentary system * Ability to drink at least 200 ml of water per day * No history of being allergic to fungi and yeast * Absence of acute medical illness * life expectancy more than 3 months * Accept and sign the consent
Exclusion criteria
* Patient's unwillingness to participate in the study * History of smoking, peritoneal dialysis (PD) or previous kidney transplantation * Lactation or pregnancy * Drug history including antibiotics, prebiotics, probiotics, herbal drugs, psychedelic drugs, flavors.
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| pre- and post-treatment p-cresol levels | 4 weeks |
Outcome results
None listed