Psoriasis
Conditions
Brief summary
Psoriasis is an immune-mediated skin disease that affects 1-2 % of the population. Several cytokines have been found to be involved in the complex pathogenesis of this disease. Il- 36 is one of the cytokines sharing in psoriasis pathogenesis, as its levels are elevated in psoriatic plaques. Cathepsin G is known to activate Il- 36 and promote inflammation in psoriasis.NB-UVB is one of the important treatment modalities for psoriasis. The aim of this study is to detect the effect of NB-UVB on the lesional levels of IL-36 in psoriasis.
Detailed description
25 psoriasis patients will receive 26 sessions of phototherapy (NB-UVB). Patients will receive 3 sessions per week. Tissue levels of IL-36 and Cathepsin G will be assessed in skin lesions before starting treatment and after completing the 26 sessions.
Interventions
DEVICENB-UVB
Phototherapy
Sponsors
Cairo University
Study design
Allocation
NA
Intervention model
SINGLE_GROUP
Primary purpose
OTHER
Masking
NONE
Eligibility
Sex/Gender
ALL
Age
18 Years to 60 Years
Healthy volunteers
No
Inclusion criteria
* Patients with psoriasis vulgaris of both sexes * Age between 18 and 60 years old.
Exclusion criteria
* Pregnant females * Patients receiving systemic treatment or topical treatment for psoriasis within the past two months. * Patients having other dermatological diseases.
Design outcomes
Primary
| Measure | Time frame | Description |
|---|---|---|
| changes in Il-36 levels in 25 psoriasis patients after 26 sessions of NB-UVB | 6 months | primary |
Secondary
| Measure | Time frame | Description |
|---|---|---|
| changes in cathepsin G levels in 25 psoriasis patients after 26 sessions of NB-UVB psoriasis | 6 months | secondary |
Outcome results
None listed