Mild Cognitive Impairment
Conditions
Keywords
Mild cognitive impairment, Neurofeedback, electroencephalography, attention, memory
Brief summary
This is a non-pharmacological study evaluating the effects of SMR/delta ratio and beta1/theta ratio neurofeedback trainings on cognitive performance and electrical brain activity in elderly with mild cognitive impairment.
Detailed description
Older adults with Mild Cognitive Impairment (MCI) are at high risk to progress to Alzheimer's disease (AD). Slowing down effect of dementia by enhancing brain plasticity represents one of the most prominent challenges. Neurofeedback is one of the promising techniques that showed therapeutic efficacy and cognitive improvement in attention-deficit hyperactivity disorder, epilepsy, stroke. We aim to study the effects of two neurofeedback training protocols, SMR/delta ratio and beta1/theta ratio, on cognitive performances in older adults with Mild Cognitive Impairment and to assess whether MCI patients change in brain electrical activity in a resting state after training.
Interventions
BEHAVIORALNeurofeedback
Neurofeedback experiment will consist of 30 sessions of neurofeedback training, twice or three times a week during maximum 4 months. The two experimental groups will undergo questionnaires, EEG recording and neuropsychological assessments in three-time points, pre-training (T0), post-training (T1) and 3 months follow-up (T2). Electroencephalography will be recorded by a technician in EEGFor each participant, EEG power spectrum will be calculated in pre (T0) and post neurofeedback training/psycho-pedagogical care at T2 and T3.
Sponsors
Fabienne Marlats
Study design
Allocation
RANDOMIZED
Intervention model
PARALLEL
Primary purpose
PREVENTION
Masking
DOUBLE (Subject, Outcomes Assessor)
Intervention model description
Comparison between three groups : two experimental groups and a control group
Eligibility
Sex/Gender
ALL
Age
60 Years to No maximum
Healthy volunteers
No
Inclusion criteria
* Clinical diagnosis of Mild Cognitive Impairment * MMSE score \>24 * Subjective memory complaint confirmed by an informant. * Perform at/or below 1.5 standard deviations from the mean for age and education-matched norms on more than one of the neuropsychological tests. * Preserve activity of daily living * Absence of dementia.
Exclusion criteria
* Psychiatric and neurological disorders * History of alcohol or other substance consumption
Design outcomes
Primary
| Measure | Time frame | Description |
|---|---|---|
| Change on attention test, TMTB-TMA | Baseline Assessment in 2 weeks period before intervention, change from baseline at immediately after the end of the intervention and after 3-months follow-up | assessment of the Trail Making Test B and A, calculation of subtraction |
Secondary
| Measure | Time frame | Description |
|---|---|---|
| Change on Rey Auditory Verbal Learning Test | Baseline assessment in 2 weeks period before intervention, change from baseline at immediately after the end of the intervention, and after 3-months follow-up | Assessment of verbal learning in episodic memory |
Contacts
Primary ContactAnne-Sophie AR Rigaud, professor
Backup ContactFabienne FM Marlats, PhD candidate
Outcome results
None listed