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Physical and Cognitive Exercises in Nursing Homes: Is Frailty Reversible?

Physical and Cognitive Exercises in Nursing Homes: Is Frailty Reversible?

Status
Completed
Phases
NA
Study type
Interventional
Source
ClinicalTrials.gov
Registry ID
NCT03526653
Enrollment
10
Registered
2018-05-16
Start date
2018-04-01
Completion date
2018-06-01
Last updated
2019-11-21

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Elderly, Physical Activity

Brief summary

Elderly in residential care spend 97% of their time sedentary. Moreover, exercise therapy often takes place in a poorly stimulating environment which is less motivational for the elderly to undertake regularly. Exercise is however necessary to preserve their physical capabilities and to limit their care dependence. The aim of this study is to investigate the most motivating and stimulating exercise modality for prefrail and frail elderly in nursing homes with which they can reach sufficient training volume. To study this, elderly will exercise in 3 different ways on an ergometer or motomed (according to their physical capabilities): 1) in an environment without other visual stimuli 2) in front of a television with National Geographic images 3) with the interactive software program MemoRide with which participants can exercise in real life on a virtual manner. MemoRide (Activ84Health) uses Google Street View images. The starting point is a connection between an exercise bike and a tablet with a pedalling sensor. This way, pedal frequency is sent to the tablet and as a result, images continue when pedalling. The forth modality is the control modality, in which participants are instructed to rest (supine) during 30 minutes. Based on objective training parameters and metabolic parameters e.g. glucose, insulin, brain-derived neurotrophic factor (BDNF) and lactate, (via a blood sample with a venous catheter) the training modality which offers the best training results will be studied. Secondly, also subject experiences (motivation and emotions) will be evaluated by using questionnaires and observation scales.

Interventions

OTHERexercise without visual stimuli

exercise on an ergometer or motomed in an environment without other visual stimuli

OTHERexcercise with National Geografics

exercise on an ergometer or motomed while watching the National Geografics channel on television

OTHERExercise with MemoRide

excercise on an ergometer or motomed with the interactive software program MemoRide with which participants can exercise in real life on a virtual manner

Sponsors

Hasselt University
Lead SponsorOTHER

Study design

Allocation
NON_RANDOMIZED
Intervention model
CROSSOVER
Primary purpose
SCREENING
Masking
SINGLE (Outcomes Assessor)

Eligibility

Sex/Gender
ALL
Age
70 Years to No maximum
Healthy volunteers
Yes

Inclusion criteria

* Men and women with an age of at least 70 years at the start of the study; * Staying for at least one month in WZC St. Elisabeth Hasselt at the start of the study; * Being frail or prefrail (according to the criteria of Fried); * Being available to participate in the study during 4 consecutive weeks; * Being able to actively exercise on an exercise bike (if necessary from a wheelchair) during at least 5 minutes; * Understand simple instructions.

Exclusion criteria

* Any neurological or orthopedic disease which makes it impossible to exercise by bike actively e.g. stroke with hemiparesis of the lower limbs, amputations of the lower limbs,…; * Any disease which makes it impossible to exercise actively e.g. heart failure; * Any neurological or orthopedic disease from which progression (e.g. hip prosthesis, acute stroke) due to active recovery or decline (e.g. ALS (amyotropic lateral sclerosis), MS) due to the disease process can be expected on short term (1-2 months); * Being blind or visually impaired; * Any acute disease on the moment of the intervention which makes it impossible to exercise by bike during 30 minutes (e.g. hyper- or hypoglycemia) (reported by the caregiver)

Design outcomes

Primary

MeasureTime frameDescription
Credibility-Expectancy Questionnaireminute 30evaluation of motivation via Credibility-Expectancy Questionnaire
Brain Derived Neurotrophic Factor (BDNF)Baselinea protein produced inside the brain which can be transported outside the brain - it probably has a protective effect on neuronal survival and maintenance during adulthood
Distance immediately post-interventionminute 30evaluation of distance via data on the exercise bike
Velocityminute 30evaluation of velocity via data on the exercise bike and pedalling sensor
Intrinsic Motivation Inventoryminute 30evaluation of motivation via Intrinsic Motivation Inventory questionaire
Observed Emotion Rating Scaleminute 30evaluation of emotions via an observation scale (Observed Emotion Rating Scale)
Fatigueminute 30evaluation of perceived exertion via the BORG-scale

Secondary

MeasureTime frameDescription
InsulinbaselineEvaluation of insulin via a blood sample
Heart ratebaselineEvaluation of heart rate via a heart rate monitor
systolic and diastolic blood pressurebaselineEvaluation of blood pressure via a blood pressure monitor
Lactateminute 30Evaluation of lactate via a finger prick
depressed feelingsbaselineEvaluation of depressed feelings via a questionnaire (Geriatric Depression Scale)
GlucosebaselineEvaluation of glucose via a blood sample

Countries

Belgium

Outcome results

None listed

Source: ClinicalTrials.gov · Data processed: Feb 4, 2026