Rabies
Conditions
Keywords
Rabies immunoglobulin
Brief summary
No study was conducted to evaluate the rabies neutralizing antibody titers after RIG injection on day 7. The only study that has supported the delay of RIG administration was done in 1996 by our institute, of which RIG was given on day 5 with the original Thai Red Cross intradermal regimen (2-2-2-0-1-1).
Detailed description
Rabies immunoglobulin (RIG) should be administered as soon as possible after the initiation of post-exposure prophylaxis. RIG should not be given after day 7 following the first rabies vaccine dose, because circulating neutralizing antibody will have begun to appear. Nevertheless, no study was conducted to evaluate the rabies neutralizing antibody titers after RIG injection on day 7. The only study that has supported the delay of RIG administration was done in 1996 by our institute, of which RIG was given on day 5 with the original Thai Red Cross intradermal regimen (2-2-2-0-1-1). The ongoing study would prove the validity of the recommendation and eliminate the controversies in clinical practice.
Interventions
BIOLOGICALEquine rabies immunoglobulin injection on day 7
The patients with WHO category III rabies exposure, who have received first dose of rabies vaccination a week before and have not received rabies immunoglobulin were enrolled. Blood for Rabies neutralizing antibody titers (RNab) would be examined on day 0. On the same day, Equine rabies immunoglobulin (ERIG) at the dosage of 40 IU/kg would be injected into and around the wound as much as possible and the rest would be injected intramuscularly at the site distance from rabies vaccine. Then blood for RNab would be serially examined on day 7, 14, 90, 365.
Sponsors
Queen Saovabha Memorial Institute
Study design
Allocation
NA
Intervention model
SINGLE_GROUP
Primary purpose
TREATMENT
Masking
NONE
Eligibility
Sex/Gender
ALL
Age
18 Years to 60 Years
Healthy volunteers
Yes
Inclusion criteria
* Age 18 - 60 years * WHO category III rabies exposure * Received rabies vaccination on day 0 and 3.
Exclusion criteria
* Received RIG * Immunocompromised hosts or receiving immunosuppressive therapy * Received blood or blood product within 3 months * Received anti-malarial drugs
Design outcomes
Primary
| Measure | Time frame | Description |
|---|---|---|
| Rabies neutralizing antibody titers | Change from baseline of geometric mean titres of rabies neutralizing antibody titres at 2 weeks | Rabies neutralizing antibody titers would be represented and compared by geometric mean titers (GMTs) |
Countries
Thailand
Contacts
Primary ContactSuda Sibunruang, MD
Backup ContactTerapong Tantawichien, MD
Outcome results
None listed