Brugada Syndrome
Conditions
Brief summary
The study purpose is to evaluate the morphological, functional and electrophysiological characteristics of the right ventricle before and after ajmaline in patients diagnosed with Brugada syndrome as well as to correlate CMR findings and substrate size.
Detailed description
All consecutive patients with either spontaneous or ajmaline-induced BrS-ECG pattern will be screened. A total of 30 BrS patients and 30 normal age, sex and BSA matched normal controls will be selected and enrolled. Patients will perform cardiac magnetic resonance imaging to evaluate and compare morphological and functional characteristics of the 2 groups before and after ajmaline. BrS patients will also perform a standardized programmed ventricular stimulation protocol and electroanatomical mapping to determine the substrate size.
Interventions
DRUGAjmaline 17-(Chloroacetate) Monohydrochloride
Ajmaline 17-(Chloroacetate) Monohydrochloride(1mg/kg in 5 minutes)
Sponsors
IRCCS Policlinico S. Donato
Study design
Observational model
COHORT
Time perspective
PROSPECTIVE
Eligibility
Sex/Gender
ALL
Age
18 Years to No maximum
Healthy volunteers
Yes
Inclusion criteria
* Brugada syndrome with either spontaneous or ajmaline- induced type 1 ECG pattern * Indication to ajmaline testing and programmed ventricular stimulation * Age \> or equal to 18 years * Written informed consent
Exclusion criteria
* Pregnancy * Contraindication to CMRI or to ajmaline * Live espectance \< 12 months
Design outcomes
Primary
| Measure | Time frame | Description |
|---|---|---|
| Electrocardiographic changes | 1 day during Electrocardiography | Changes of PR, QRS, and QT parameters, before and after ajmaline in Brugada patients as compared with control subjects |
| MRI changes of left and right ventricular function | 1day during MRI | MRI changes of left and right ventricular function before and after ajmaline in Brugada patients as compared with control subjects |
| CMR parameters changes of the right and left ventricle function | 1 day during CMR | Changes of right ventricular areal strain before and after ajmaline in Brugada patients as compared with controls |
| Electrical substrate changes of the right ventricle | 1 day after ICD implantation | electroanatomical epicardial mapping for substrate determination before and after ajmaline |
Countries
Italy
Outcome results
None listed